Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity
Small conductance calcium-activated potassium channels (SK channels) are present in spines and can be activated by backpropagating action potentials (APs). This suggests they may play a critical role in spike-timing dependent synaptic plasticity (STDP). Consistent with this idea, EPSPs in both corti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-10-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/30333 |
| _version_ | 1811200230916358144 |
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| author | Scott L Jones Minh-Son To Greg J Stuart |
| author_facet | Scott L Jones Minh-Son To Greg J Stuart |
| author_sort | Scott L Jones |
| collection | DOAJ |
| description | Small conductance calcium-activated potassium channels (SK channels) are present in spines and can be activated by backpropagating action potentials (APs). This suggests they may play a critical role in spike-timing dependent synaptic plasticity (STDP). Consistent with this idea, EPSPs in both cortical and hippocampal pyramidal neurons were suppressed by preceding APs in an SK-dependent manner. In cortical pyramidal neurons EPSP suppression by preceding APs depended on their precise timing as well as the distance of activated synapses from the soma, was dendritic in origin, and involved SK-dependent suppression of NMDA receptor activation. As a result SK channel activation by backpropagating APs gated STDP induction during low-frequency AP-EPSP pairing, with both LTP and LTD absent under control conditions but present after SK channel block. These findings indicate that activation of SK channels in spines by backpropagating APs plays a key role in regulating both EPSP amplitude and STDP induction. |
| first_indexed | 2024-04-12T02:01:07Z |
| format | Article |
| id | doaj.art-379a275c7c3a4ace8ba9b46fd9fce858 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:01:07Z |
| publishDate | 2017-10-01 |
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| spelling | doaj.art-379a275c7c3a4ace8ba9b46fd9fce8582022-12-22T03:52:40ZengeLife Sciences Publications LtdeLife2050-084X2017-10-01610.7554/eLife.30333Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticityScott L Jones0Minh-Son To1Greg J Stuart2https://orcid.org/0000-0001-9395-2219Eccles Institute of Neuroscience and Australian Research Council Centre of Excellence for Integrative Brain Function, John Curtin School of Medical Research, Australian National University, Canberra, AustraliaEccles Institute of Neuroscience and Australian Research Council Centre of Excellence for Integrative Brain Function, John Curtin School of Medical Research, Australian National University, Canberra, Australia; Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, AustraliaEccles Institute of Neuroscience and Australian Research Council Centre of Excellence for Integrative Brain Function, John Curtin School of Medical Research, Australian National University, Canberra, AustraliaSmall conductance calcium-activated potassium channels (SK channels) are present in spines and can be activated by backpropagating action potentials (APs). This suggests they may play a critical role in spike-timing dependent synaptic plasticity (STDP). Consistent with this idea, EPSPs in both cortical and hippocampal pyramidal neurons were suppressed by preceding APs in an SK-dependent manner. In cortical pyramidal neurons EPSP suppression by preceding APs depended on their precise timing as well as the distance of activated synapses from the soma, was dendritic in origin, and involved SK-dependent suppression of NMDA receptor activation. As a result SK channel activation by backpropagating APs gated STDP induction during low-frequency AP-EPSP pairing, with both LTP and LTD absent under control conditions but present after SK channel block. These findings indicate that activation of SK channels in spines by backpropagating APs plays a key role in regulating both EPSP amplitude and STDP induction.https://elifesciences.org/articles/30333Action potentialEPSPplasticitySK channelNMDA |
| spellingShingle | Scott L Jones Minh-Son To Greg J Stuart Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity eLife Action potential EPSP plasticity SK channel NMDA |
| title | Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity |
| title_full | Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity |
| title_fullStr | Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity |
| title_full_unstemmed | Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity |
| title_short | Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity |
| title_sort | dendritic small conductance calcium activated potassium channels activated by action potentials suppress epsps and gate spike timing dependent synaptic plasticity |
| topic | Action potential EPSP plasticity SK channel NMDA |
| url | https://elifesciences.org/articles/30333 |
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