HDACs control RUNX2 expression in cancer cells through redundant and cell context-dependent mechanisms

HDACs control RUNX2 expression in cancer cells through redundant and cell context-dependent mechanisms

Abstract Background RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid and breast gland. Consistent evidence indicates that RUNX2 expression is aberrantly reactivated in cancer and supports tumor pro...

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Bibliographic Details
Main Authors: Gloria Manzotti, Federica Torricelli, Benedetta Donati, Valentina Sancisi, Mila Gugnoni, Alessia Ciarrocchi
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
RUNX2
HDACs
Gene expression regulation
HDAC inhibitors
Cancer
Online Access:http://link.springer.com/article/10.1186/s13046-019-1350-5

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