Computational conjugate adaptive optics microscopy for longitudinal through-skull imaging of cortical myelin

The authors realize longitudinal deep-brain imaging through an intact mouse skull by constructing a high-speed reflection matrix microscope at 1.3 µm wavelength and developing a computational conjugate adaptive optics algorithm eliminating skull aberrations.

Bibliographic Details
Main Authors: Yongwoo Kwon, Jin Hee Hong, Sungsam Kang, Hojun Lee, Yonghyeon Jo, Ki Hean Kim, Seokchan Yoon, Wonshik Choi
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35738-9