Between a rock and a hard place: management of systemic lupus erythematosus and porphyria cutanea tarda
Porphyria cutanea tarda (PCT), the most common porphyria, is a rare photodermatosis characterized by fragile, hemorrhagic bullae and erosions with associated milia, hyperpigmentation, and hypertrichosis. SLE is a systemic connective tissue disease with approximately 80% of those affected manifesting...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-07-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2022.2060925 |
| _version_ | 1797683525363695616 |
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| author | Timothy Nyckowski Alexandra Grammenos Alisa Vinokurov Rajiv Nathoo |
| author_facet | Timothy Nyckowski Alexandra Grammenos Alisa Vinokurov Rajiv Nathoo |
| author_sort | Timothy Nyckowski |
| collection | DOAJ |
| description | Porphyria cutanea tarda (PCT), the most common porphyria, is a rare photodermatosis characterized by fragile, hemorrhagic bullae and erosions with associated milia, hyperpigmentation, and hypertrichosis. SLE is a systemic connective tissue disease with approximately 80% of those affected manifesting cutaneous findings. These include malar and discoid rashes, photosensitivity, bullae, oral ulcerations, as well as a variety of other nonspecific findings. In this case, we illustrate a rare but established association between these two pathologic entities, and the resulting therapeutic challenge in treating a patient with both conditions. The concurrence of these two diseases poses therapeutic challenges with a paucity of evidence-based recommendations. Management with low dose weekly antimalarial therapy may be the appropriate middle ground in effectively treating the two co-morbid conditions especially in a patient with other underlying systemic conditions. |
| first_indexed | 2024-03-12T00:15:48Z |
| format | Article |
| id | doaj.art-379c4efcff954d3ab1b22d6ab6b3cc4e |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:15:48Z |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-379c4efcff954d3ab1b22d6ab6b3cc4e2023-09-15T14:28:51ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-07-013352689269110.1080/09546634.2022.20609252060925Between a rock and a hard place: management of systemic lupus erythematosus and porphyria cutanea tardaTimothy Nyckowski0Alexandra Grammenos1Alisa Vinokurov2Rajiv Nathoo3Orlando Dermatology, Graduate Medical Education Consortium, Kansas City UniversityOrlando Dermatology, Graduate Medical Education Consortium, Kansas City UniversityAdvent Health Orlando Pharmacy ResidencyOrlando Dermatology, Graduate Medical Education Consortium, Kansas City UniversityPorphyria cutanea tarda (PCT), the most common porphyria, is a rare photodermatosis characterized by fragile, hemorrhagic bullae and erosions with associated milia, hyperpigmentation, and hypertrichosis. SLE is a systemic connective tissue disease with approximately 80% of those affected manifesting cutaneous findings. These include malar and discoid rashes, photosensitivity, bullae, oral ulcerations, as well as a variety of other nonspecific findings. In this case, we illustrate a rare but established association between these two pathologic entities, and the resulting therapeutic challenge in treating a patient with both conditions. The concurrence of these two diseases poses therapeutic challenges with a paucity of evidence-based recommendations. Management with low dose weekly antimalarial therapy may be the appropriate middle ground in effectively treating the two co-morbid conditions especially in a patient with other underlying systemic conditions.http://dx.doi.org/10.1080/09546634.2022.2060925systemic lupus erythematosusporphyria cutanea tardahydroxychloroquineantimalarialsbullae |
| spellingShingle | Timothy Nyckowski Alexandra Grammenos Alisa Vinokurov Rajiv Nathoo Between a rock and a hard place: management of systemic lupus erythematosus and porphyria cutanea tarda Journal of Dermatological Treatment systemic lupus erythematosus porphyria cutanea tarda hydroxychloroquine antimalarials bullae |
| title | Between a rock and a hard place: management of systemic lupus erythematosus and porphyria cutanea tarda |
| title_full | Between a rock and a hard place: management of systemic lupus erythematosus and porphyria cutanea tarda |
| title_fullStr | Between a rock and a hard place: management of systemic lupus erythematosus and porphyria cutanea tarda |
| title_full_unstemmed | Between a rock and a hard place: management of systemic lupus erythematosus and porphyria cutanea tarda |
| title_short | Between a rock and a hard place: management of systemic lupus erythematosus and porphyria cutanea tarda |
| title_sort | between a rock and a hard place management of systemic lupus erythematosus and porphyria cutanea tarda |
| topic | systemic lupus erythematosus porphyria cutanea tarda hydroxychloroquine antimalarials bullae |
| url | http://dx.doi.org/10.1080/09546634.2022.2060925 |
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