Mutations in Complex I of the Mitochondrial Electron-Transport Chain Sensitize the Fruit Fly (<i>Drosophila melanogaster</i>) to Ether and Non-Ether Volatile Anesthetics

Mutations in Complex I of the Mitochondrial Electron-Transport Chain Sensitize the Fruit Fly (<i>Drosophila melanogaster</i>) to Ether and Non-Ether Volatile Anesthetics

The mitochondrial electron transport chain (mETC) contains molecular targets of volatile general anesthetics (VGAs), which places carriers of mutations at risk for anesthetic complications. The <i>ND-23<sup>60114</sup></i> and mt:<i>ND2<sup>del1</sup></i&...

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Bibliographic Details
Main Authors: Luke A. Borchardt, Amanda R. Scharenbrock, Zachariah P. G. Olufs, David A. Wassarman, Misha Perouansky
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
electron transport chain
volatile anesthetics
mutations
Complex I
toxicity
Online Access:https://www.mdpi.com/1422-0067/24/3/1843

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