Dual MGMT inactivation by promoter hypermethylation and loss of the long arm of chromosome 10 in glioblastoma

Dual MGMT inactivation by promoter hypermethylation and loss of the long arm of chromosome 10 in glioblastoma

Abstract Background Epigenetic inactivation of O6‐methylguanine‐methyltransferase (MGMT) gene by methylation of its promoter is predictive of Temozolomid (TMZ) response in glioblastoma (GBM). MGMT is located on chromosome 10q26 and the loss of chromosome 10q is observed in 70% of GBMs. In this study...

Full description

Bibliographic Details
Main Authors: Sophie Richard, Gaëlle Tachon, Serge Milin, Michel Wager, Lucie Karayan‐Tapon
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Cancer Medicine
Subjects:
10q
comparative genomic hybridization
glioblastoma
loss of heterozygosity
MGMT
Online Access:https://doi.org/10.1002/cam4.3217

Similar Items

Similar Items