The inhibitory control of traveling waves in cortical networks.
Propagating waves of activity can be evoked and can occur spontaneously in vivo and in vitro in cerebral cortex. These waves are thought to be instrumental in the propagation of information across cortical regions and as a means to modulate the sensitivity of neurons to subsequent stimuli. In normal...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-09-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010697&type=printable |
| _version_ | 1797674051028647936 |
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| author | Grishma Palkar Jian-Young Wu Bard Ermentrout |
| author_facet | Grishma Palkar Jian-Young Wu Bard Ermentrout |
| author_sort | Grishma Palkar |
| collection | DOAJ |
| description | Propagating waves of activity can be evoked and can occur spontaneously in vivo and in vitro in cerebral cortex. These waves are thought to be instrumental in the propagation of information across cortical regions and as a means to modulate the sensitivity of neurons to subsequent stimuli. In normal tissue, the waves are sparse and tightly controlled by inhibition and other negative feedback processes. However, alterations of this balance between excitation and inhibition can lead to pathological behavior such as seizure-type dynamics (with low inhibition) or failure to propagate (with high inhibition). We develop a spiking one-dimensional network of neurons to explore the reliability and control of evoked waves and compare this to a cortical slice preparation where the excitability can be pharmacologically manipulated. We show that the waves enhance sensitivity of the cortical network to stimuli in specific spatial and temporal ways. To gain further insight into the mechanisms of propagation and transitions to pathological behavior, we derive a mean-field model for the synaptic activity. We analyze the mean-field model and a piece-wise constant approximation of it and study the stability of the propagating waves as spatial and temporal properties of the inhibition are altered. We show that that the transition to seizure-like activity is gradual but that the loss of propagation is abrupt and can occur via either the loss of existence of the wave or through a loss of stability leading to complex patterns of propagation. |
| first_indexed | 2024-03-11T21:54:32Z |
| format | Article |
| id | doaj.art-379ebbb70f614ba0b3bc97eef26cee26 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-03-11T21:54:32Z |
| publishDate | 2023-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-379ebbb70f614ba0b3bc97eef26cee262023-09-26T05:30:47ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582023-09-01199e101069710.1371/journal.pcbi.1010697The inhibitory control of traveling waves in cortical networks.Grishma PalkarJian-Young WuBard ErmentroutPropagating waves of activity can be evoked and can occur spontaneously in vivo and in vitro in cerebral cortex. These waves are thought to be instrumental in the propagation of information across cortical regions and as a means to modulate the sensitivity of neurons to subsequent stimuli. In normal tissue, the waves are sparse and tightly controlled by inhibition and other negative feedback processes. However, alterations of this balance between excitation and inhibition can lead to pathological behavior such as seizure-type dynamics (with low inhibition) or failure to propagate (with high inhibition). We develop a spiking one-dimensional network of neurons to explore the reliability and control of evoked waves and compare this to a cortical slice preparation where the excitability can be pharmacologically manipulated. We show that the waves enhance sensitivity of the cortical network to stimuli in specific spatial and temporal ways. To gain further insight into the mechanisms of propagation and transitions to pathological behavior, we derive a mean-field model for the synaptic activity. We analyze the mean-field model and a piece-wise constant approximation of it and study the stability of the propagating waves as spatial and temporal properties of the inhibition are altered. We show that that the transition to seizure-like activity is gradual but that the loss of propagation is abrupt and can occur via either the loss of existence of the wave or through a loss of stability leading to complex patterns of propagation.https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010697&type=printable |
| spellingShingle | Grishma Palkar Jian-Young Wu Bard Ermentrout The inhibitory control of traveling waves in cortical networks. PLoS Computational Biology |
| title | The inhibitory control of traveling waves in cortical networks. |
| title_full | The inhibitory control of traveling waves in cortical networks. |
| title_fullStr | The inhibitory control of traveling waves in cortical networks. |
| title_full_unstemmed | The inhibitory control of traveling waves in cortical networks. |
| title_short | The inhibitory control of traveling waves in cortical networks. |
| title_sort | inhibitory control of traveling waves in cortical networks |
| url | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010697&type=printable |
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