A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhage
Objectives: This study aimed to determine whether SII on different days of admission is associated with severity and 180-day functional outcomes after basal ganglia ICH. Methods: In this retrospective study, data on baseline CT imaging characteristics, mRS, hematoma volume, and laboratory variables...
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Elsevier
2023-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023041440 |
| _version_ | 1797807035036729344 |
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| author | Zhang Liang He Liu Li Xue Bin Ma Ling-Zhi Yang Qing-Le Liang Zhang-Ming Zhou |
| author_facet | Zhang Liang He Liu Li Xue Bin Ma Ling-Zhi Yang Qing-Le Liang Zhang-Ming Zhou |
| author_sort | Zhang Liang |
| collection | DOAJ |
| description | Objectives: This study aimed to determine whether SII on different days of admission is associated with severity and 180-day functional outcomes after basal ganglia ICH. Methods: In this retrospective study, data on baseline CT imaging characteristics, mRS, hematoma volume, and laboratory variables were included. The SII and NLR, LMR, and PLR were calculated from laboratory data collected on admission day, day 1, and days 5–7. Both univariate and multivariable logistic regression analyses were used to assess the association between the SII and the outcome. The receiver operating characteristic (ROC) analysis and area under the curve (AUC) were also used to evaluate the ability of the SII to predict outcomes. Result: A total of 245 patients were enrolled in the study. On different days, the NLR, PLR, and SII were significantly lower in patients with favorable outcomes than in those with poor outcomes, and the volume of hemorrhage was positively correlated with the SII. These parameters were associated with outcomes in the univariate logistic regression. In the adjusted analyses, the SII and PLR were independent predictors of basal ganglia ICH outcomes. ROC analysis revealed that the SII showed a stronger ability to predict the 6-month outcomes of patients after basal ganglia ICH than the PLR on different days (AUC = 0.642, 0.804, 0.827 vs. 0.592, 0.725, 0.757; all P < 0.001). Conclusion: The SII independently and strongly predicts the outcome of basal ganglia ICH. A high SII was associated with poor 6-month outcomes in patients with basal ganglia ICH. |
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| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T06:16:27Z |
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| series | Heliyon |
| spelling | doaj.art-379f3bd5530f4a1e94db12d022455bbd2023-06-11T04:14:45ZengElsevierHeliyon2405-84402023-06-0196e16937A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhageZhang Liang0He Liu1Li Xue2Bin Ma3Ling-Zhi Yang4Qing-Le Liang5Zhang-Ming Zhou6Department of Neurosurgery, Dujiangyan Medical Center, Chengdu, ChinaDepartment of Radiology, First Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Orthopaedics, The 3rd People’s Hospital of Chengdu, College of Medicine, Southwest Jiaotong University, Chengdu, ChinaHuman Anatomy, College of Science, Health, Engineering and Education, Murdoch University, Perth, AustraliaDepartment of Clinical Laboratory Medicine, Dujiangyan Medical Center, Chengdu, ChinaDepartment of Clinical Laboratory Medicine, Jiangjin Affiliated Hospital, Chongqing University, Chongqing, China; Corresponding author.Department of Neurosurgery, Dujiangyan Medical Center, Chengdu, China; Corresponding author.Objectives: This study aimed to determine whether SII on different days of admission is associated with severity and 180-day functional outcomes after basal ganglia ICH. Methods: In this retrospective study, data on baseline CT imaging characteristics, mRS, hematoma volume, and laboratory variables were included. The SII and NLR, LMR, and PLR were calculated from laboratory data collected on admission day, day 1, and days 5–7. Both univariate and multivariable logistic regression analyses were used to assess the association between the SII and the outcome. The receiver operating characteristic (ROC) analysis and area under the curve (AUC) were also used to evaluate the ability of the SII to predict outcomes. Result: A total of 245 patients were enrolled in the study. On different days, the NLR, PLR, and SII were significantly lower in patients with favorable outcomes than in those with poor outcomes, and the volume of hemorrhage was positively correlated with the SII. These parameters were associated with outcomes in the univariate logistic regression. In the adjusted analyses, the SII and PLR were independent predictors of basal ganglia ICH outcomes. ROC analysis revealed that the SII showed a stronger ability to predict the 6-month outcomes of patients after basal ganglia ICH than the PLR on different days (AUC = 0.642, 0.804, 0.827 vs. 0.592, 0.725, 0.757; all P < 0.001). Conclusion: The SII independently and strongly predicts the outcome of basal ganglia ICH. A high SII was associated with poor 6-month outcomes in patients with basal ganglia ICH.http://www.sciencedirect.com/science/article/pii/S2405844023041440Basal ganglia intracerebral hemorrhage (ICH)Prognostic markerSystemic immune-inflammation index (SII)BiomarkersInflammation |
| spellingShingle | Zhang Liang He Liu Li Xue Bin Ma Ling-Zhi Yang Qing-Le Liang Zhang-Ming Zhou A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhage Heliyon Basal ganglia intracerebral hemorrhage (ICH) Prognostic marker Systemic immune-inflammation index (SII) Biomarkers Inflammation |
| title | A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhage |
| title_full | A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhage |
| title_fullStr | A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhage |
| title_full_unstemmed | A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhage |
| title_short | A retrospective study about association of dynamic systemic immune-inflammation index (SII) with 180-day functional outcome after basal ganglia intracerebral hemorrhage |
| title_sort | retrospective study about association of dynamic systemic immune inflammation index sii with 180 day functional outcome after basal ganglia intracerebral hemorrhage |
| topic | Basal ganglia intracerebral hemorrhage (ICH) Prognostic marker Systemic immune-inflammation index (SII) Biomarkers Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023041440 |
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