Sox10-Deficient Drug-Resistant Melanoma Cells Are Refractory to Oncolytic RNA Viruses

Sox10-Deficient Drug-Resistant Melanoma Cells Are Refractory to Oncolytic RNA Viruses

Targeted therapy resistance frequently develops in melanoma due to intratumor heterogeneity and epigenetic reprogramming. This also typically induces cross-resistance to immunotherapies. Whether this includes additional modes of therapy has not been fully assessed. We show that co-treatments of MAPK...

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Bibliographic Details
Main Authors: John Abou-Hamad, Jonathan J. Hodgins, Edward Yakubovich, Barbara C. Vanderhyden, Michele Ardolino, Luc A. Sabourin
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
melanoma
SOX10
BRAFV600E
oncolytics
vemurafenib
drug resistance
Online Access:https://www.mdpi.com/2073-4409/13/1/73

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