DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops

DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops

Summary: Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches and cellular analysis of specific mutants have uncovered factors potentially involved in R-loop homeostasis, we report a more open screening of factors whose depleti...

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Bibliographic Details
Main Authors: Esther Marchena-Cruz, Lola P. Camino, Jay Bhandari, Sónia Silva, José Javier Marqueta-Gracia, Shahad A. Amdeen, Cristina Guillén-Mendoza, María L. García-Rubio, José M. Calderón-Montaño, Xiaoyu Xue, Rosa Luna, Andrés Aguilera
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723001596

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