Brain Gray Matter Volume Associations With Abnormal Gait Imagery in Patients With Mild Cognitive Impairment: Results of a Cross-Sectional Study
Individuals with mild cognitive impairment (MCI) have worse gait performance compared to cognitive healthy individuals (CHI). The discrepancy between imagined and performed timed up and go test (TUG), known as the TUG delta time, is a marker of brain gait control impairment in individuals with MCI....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00364/full |
| _version_ | 1818905562679607296 |
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| author | Olivier Beauchet Olivier Beauchet Olivier Beauchet Olivier Beauchet Maxime Montembeault Maxime Montembeault Gilles Allali |
| author_facet | Olivier Beauchet Olivier Beauchet Olivier Beauchet Olivier Beauchet Maxime Montembeault Maxime Montembeault Gilles Allali |
| author_sort | Olivier Beauchet |
| collection | DOAJ |
| description | Individuals with mild cognitive impairment (MCI) have worse gait performance compared to cognitive healthy individuals (CHI). The discrepancy between imagined and performed timed up and go test (TUG), known as the TUG delta time, is a marker of brain gait control impairment in individuals with MCI. The study aims to examine the association between the TUG delta time and brain gray matter (GM) volumes in CHI and individuals with MCI. A total of 326 participants, 156 CHI and 170 MCI, with TUG delta time and a brain T1-weighted magnetic resonance imaging (MRI) were selected in this cross-sectional study. Individuals with MCI were older and had greater (i.e., worst performance) performed TUG and TUG delta time compared to CHI. The GM volume association with TUG delta time was examined in CHI and MCI assuming that increased TUG delta time would be associated with locally decreased GM volumes. No significant association was found in CHI, whereas TUG delta time was negatively associated with the GM volume of the right medial temporal lobe in individuals with MCI. |
| first_indexed | 2024-12-19T21:25:19Z |
| format | Article |
| id | doaj.art-379faedc5483414da1d866a04baca416 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-19T21:25:19Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-379faedc5483414da1d866a04baca4162022-12-21T20:05:09ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-01-011110.3389/fnagi.2019.00364478403Brain Gray Matter Volume Associations With Abnormal Gait Imagery in Patients With Mild Cognitive Impairment: Results of a Cross-Sectional StudyOlivier Beauchet0Olivier Beauchet1Olivier Beauchet2Olivier Beauchet3Maxime Montembeault4Maxime Montembeault5Gilles Allali6Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis—Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, QC, CanadaDr. Joseph Kaufmann Chair in Geriatric Medicine, Faculty of Medicine, McGill University, Montreal, QC, CanadaCentre of Excellence on Longevity, McGill Integrated University Health Network, Montreal, QC, CanadaLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SingaporeCentre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, Montréal, QC, CanadaDépartement de Psychologie, Université de Montréal, Montréal, QC, CanadaDepartment of Neurology, Geneva University Hospital and University of Geneva, Geneva, SwitzerlandIndividuals with mild cognitive impairment (MCI) have worse gait performance compared to cognitive healthy individuals (CHI). The discrepancy between imagined and performed timed up and go test (TUG), known as the TUG delta time, is a marker of brain gait control impairment in individuals with MCI. The study aims to examine the association between the TUG delta time and brain gray matter (GM) volumes in CHI and individuals with MCI. A total of 326 participants, 156 CHI and 170 MCI, with TUG delta time and a brain T1-weighted magnetic resonance imaging (MRI) were selected in this cross-sectional study. Individuals with MCI were older and had greater (i.e., worst performance) performed TUG and TUG delta time compared to CHI. The GM volume association with TUG delta time was examined in CHI and MCI assuming that increased TUG delta time would be associated with locally decreased GM volumes. No significant association was found in CHI, whereas TUG delta time was negatively associated with the GM volume of the right medial temporal lobe in individuals with MCI.https://www.frontiersin.org/article/10.3389/fnagi.2019.00364/fullMRIagedbrainmotricityEPI-epidemiology |
| spellingShingle | Olivier Beauchet Olivier Beauchet Olivier Beauchet Olivier Beauchet Maxime Montembeault Maxime Montembeault Gilles Allali Brain Gray Matter Volume Associations With Abnormal Gait Imagery in Patients With Mild Cognitive Impairment: Results of a Cross-Sectional Study Frontiers in Aging Neuroscience MRI aged brain motricity EPI-epidemiology |
| title | Brain Gray Matter Volume Associations With Abnormal Gait Imagery in Patients With Mild Cognitive Impairment: Results of a Cross-Sectional Study |
| title_full | Brain Gray Matter Volume Associations With Abnormal Gait Imagery in Patients With Mild Cognitive Impairment: Results of a Cross-Sectional Study |
| title_fullStr | Brain Gray Matter Volume Associations With Abnormal Gait Imagery in Patients With Mild Cognitive Impairment: Results of a Cross-Sectional Study |
| title_full_unstemmed | Brain Gray Matter Volume Associations With Abnormal Gait Imagery in Patients With Mild Cognitive Impairment: Results of a Cross-Sectional Study |
| title_short | Brain Gray Matter Volume Associations With Abnormal Gait Imagery in Patients With Mild Cognitive Impairment: Results of a Cross-Sectional Study |
| title_sort | brain gray matter volume associations with abnormal gait imagery in patients with mild cognitive impairment results of a cross sectional study |
| topic | MRI aged brain motricity EPI-epidemiology |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2019.00364/full |
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