Metacognitions in Patients With Frequent Mental Disorders After Diagnosis of Pulmonary Arterial Hypertension
BackgroundThe prevalence of mental disorders, particularly adjustment disorder (AD), major depressive disorder (MDD) and panic disorder (PD) is increased in patients with pulmonary arterial hypertension (PAH). However, it is unclear which pathogenic mechanisms determine their development and could t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.812812/full |
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| author | Flora Caldarone Philippa Gebhardt Marius M. Hoeper Marius M. Hoeper Karen M. Olsson Karen M. Olsson Jan Fuge Jan Fuge Da-Hee Park Da-Hee Park Tanja Meltendorf Tanja Meltendorf Jan C. Kamp Jan C. Kamp Britta Stapel Manuel J. Richter Henning Gall Hossein A. Ghofrani Hossein A. Ghofrani Kai G. Kahl Ivo Heitland |
| author_facet | Flora Caldarone Philippa Gebhardt Marius M. Hoeper Marius M. Hoeper Karen M. Olsson Karen M. Olsson Jan Fuge Jan Fuge Da-Hee Park Da-Hee Park Tanja Meltendorf Tanja Meltendorf Jan C. Kamp Jan C. Kamp Britta Stapel Manuel J. Richter Henning Gall Hossein A. Ghofrani Hossein A. Ghofrani Kai G. Kahl Ivo Heitland |
| author_sort | Flora Caldarone |
| collection | DOAJ |
| description | BackgroundThe prevalence of mental disorders, particularly adjustment disorder (AD), major depressive disorder (MDD) and panic disorder (PD) is increased in patients with pulmonary arterial hypertension (PAH). However, it is unclear which pathogenic mechanisms determine their development and could therefore be targeted in prevention or therapeutic interventions. Here, we assessed metacognitions in a sample of PAH patients with and without MDD and PD. Moreover, we reconstructed the course of mental illnesses following the PAH diagnosis.MethodsTwo hundred seventeen PAH patients were included in this cross-sectional study. The prevalence of AD was assessed retrospectively using DSM-V criteria. Current mental disorders were assessed using the structured clinical interview for DSM-V. Additionally, metacognitive beliefs and processes were assessed using established questionnaires (MCQ-30, AnTI).ResultsPatients with an AD consecutive to the PAH diagnosis more frequently developed MDD (37.5 vs. 13.9%, p < 0.001) and PD (26.3 vs. 8.8%, p = 0.001) later on compared to PAH patients without a former AD. Moreover, patients with current MDD/PD displayed more dysfunctional metacognitions than those without current MDD/PD (p < 0.001). Patients with current MDD/PD in the context of former AD had more dysfunctional metacognitive worries and beliefs compared to patients with current MDD/PD without former AD (p = 0.009).ConclusionOur results suggest that in the context of PAH, dysfunctional metacognitions are associated with MDD and PD. Therefore, a metacognitive approach to treat and prevent those mental illnesses seems promising and should be investigated in future studies. |
| first_indexed | 2024-12-12T22:26:40Z |
| format | Article |
| id | doaj.art-37a55f8661b04641bdd50c307bf20891 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-12T22:26:40Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-37a55f8661b04641bdd50c307bf208912022-12-22T00:09:43ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-04-011310.3389/fpsyt.2022.812812812812Metacognitions in Patients With Frequent Mental Disorders After Diagnosis of Pulmonary Arterial HypertensionFlora Caldarone0Philippa Gebhardt1Marius M. Hoeper2Marius M. Hoeper3Karen M. Olsson4Karen M. Olsson5Jan Fuge6Jan Fuge7Da-Hee Park8Da-Hee Park9Tanja Meltendorf10Tanja Meltendorf11Jan C. Kamp12Jan C. Kamp13Britta Stapel14Manuel J. Richter15Henning Gall16Hossein A. Ghofrani17Hossein A. Ghofrani18Kai G. Kahl19Ivo Heitland20Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, GermanyDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Member of the German Center for Lung Research (DZL/BREATH), Hannover, GermanyBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Member of the German Center for Lung Research (DZL/BREATH), Hannover, GermanyBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Member of the German Center for Lung Research (DZL/BREATH), Hannover, GermanyBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Member of the German Center for Lung Research (DZL/BREATH), Hannover, GermanyBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, GermanyDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Member of the German Center for Lung Research (DZL/BREATH), Hannover, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Member of the German Center for Lung Research (DZL/BREATH), Hannover, GermanyBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, GermanyDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, GermanyDepartment of Internal Medicine, German Center for Lung Research (DZL), Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, GermanyDepartment of Internal Medicine, German Center for Lung Research (DZL), Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, GermanyDepartment of Internal Medicine, German Center for Lung Research (DZL), Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, GermanyDepartment of Pneumology, German Center for Lung Research (DZL), Kerckhoff Heart, Rheuma and Thoracic Center, Universities of Giessen and Marburg Lung Center, Bad Nauheim, GermanyDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, GermanyDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, GermanyBackgroundThe prevalence of mental disorders, particularly adjustment disorder (AD), major depressive disorder (MDD) and panic disorder (PD) is increased in patients with pulmonary arterial hypertension (PAH). However, it is unclear which pathogenic mechanisms determine their development and could therefore be targeted in prevention or therapeutic interventions. Here, we assessed metacognitions in a sample of PAH patients with and without MDD and PD. Moreover, we reconstructed the course of mental illnesses following the PAH diagnosis.MethodsTwo hundred seventeen PAH patients were included in this cross-sectional study. The prevalence of AD was assessed retrospectively using DSM-V criteria. Current mental disorders were assessed using the structured clinical interview for DSM-V. Additionally, metacognitive beliefs and processes were assessed using established questionnaires (MCQ-30, AnTI).ResultsPatients with an AD consecutive to the PAH diagnosis more frequently developed MDD (37.5 vs. 13.9%, p < 0.001) and PD (26.3 vs. 8.8%, p = 0.001) later on compared to PAH patients without a former AD. Moreover, patients with current MDD/PD displayed more dysfunctional metacognitions than those without current MDD/PD (p < 0.001). Patients with current MDD/PD in the context of former AD had more dysfunctional metacognitive worries and beliefs compared to patients with current MDD/PD without former AD (p = 0.009).ConclusionOur results suggest that in the context of PAH, dysfunctional metacognitions are associated with MDD and PD. Therefore, a metacognitive approach to treat and prevent those mental illnesses seems promising and should be investigated in future studies.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.812812/fullpulmonary arterial hypertension (PAH)pulmonary hypertensionadjustment disorderdepressive disorderpanic disordermetacognitions |
| spellingShingle | Flora Caldarone Philippa Gebhardt Marius M. Hoeper Marius M. Hoeper Karen M. Olsson Karen M. Olsson Jan Fuge Jan Fuge Da-Hee Park Da-Hee Park Tanja Meltendorf Tanja Meltendorf Jan C. Kamp Jan C. Kamp Britta Stapel Manuel J. Richter Henning Gall Hossein A. Ghofrani Hossein A. Ghofrani Kai G. Kahl Ivo Heitland Metacognitions in Patients With Frequent Mental Disorders After Diagnosis of Pulmonary Arterial Hypertension Frontiers in Psychiatry pulmonary arterial hypertension (PAH) pulmonary hypertension adjustment disorder depressive disorder panic disorder metacognitions |
| title | Metacognitions in Patients With Frequent Mental Disorders After Diagnosis of Pulmonary Arterial Hypertension |
| title_full | Metacognitions in Patients With Frequent Mental Disorders After Diagnosis of Pulmonary Arterial Hypertension |
| title_fullStr | Metacognitions in Patients With Frequent Mental Disorders After Diagnosis of Pulmonary Arterial Hypertension |
| title_full_unstemmed | Metacognitions in Patients With Frequent Mental Disorders After Diagnosis of Pulmonary Arterial Hypertension |
| title_short | Metacognitions in Patients With Frequent Mental Disorders After Diagnosis of Pulmonary Arterial Hypertension |
| title_sort | metacognitions in patients with frequent mental disorders after diagnosis of pulmonary arterial hypertension |
| topic | pulmonary arterial hypertension (PAH) pulmonary hypertension adjustment disorder depressive disorder panic disorder metacognitions |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.812812/full |
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