Does Medication-Related Osteonecrosis of the Jaw Influence the Quality of Life of Cancer Patients?
The aim of this study is to observe the influence of Medication-Related Osteonecrosis of the Jaw (MRONJ) on the physical and mental conditions of cancer patients using a Quality of Life (QoL) questionnaire during regular dental practice measures. Twenty cancer patients (8 males and 12 females) with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/4/95 |
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| author | Gianluca Tenore Ahmed Mohsen Antonella Francesca Rossi Gaspare Palaia Federica Rocchetti Andrea Cassoni Valentino Valentini Livia Ottolenghi Antonella Polimeni Umberto Romeo |
| author_facet | Gianluca Tenore Ahmed Mohsen Antonella Francesca Rossi Gaspare Palaia Federica Rocchetti Andrea Cassoni Valentino Valentini Livia Ottolenghi Antonella Polimeni Umberto Romeo |
| author_sort | Gianluca Tenore |
| collection | DOAJ |
| description | The aim of this study is to observe the influence of Medication-Related Osteonecrosis of the Jaw (MRONJ) on the physical and mental conditions of cancer patients using a Quality of Life (QoL) questionnaire during regular dental practice measures. Twenty cancer patients (8 males and 12 females) with established MRONJ were enrolled in the “MoMax” (Oral Medicine and Maxillofacial) project of the Department of Oral Sciences and Maxillofacial Surgery at “Sapienza” University of Rome, and were included in the study. The 12-item Short Form Survey was used to evaluate the QoL. Statistical analysis revealed a significant difference for Mental Component Summary (MCS) scores based on age (<i>p</i> = 0.018). The regression analysis revealed that the Physical Component Summary (PCS) scores were negatively influenced by the anti-resorptive medication duration (<i>p</i> = 0.031 and β = −1.137). No significant differences were observed with the other variables considered. The QoL of cancer patients is generally deteriorated and MRONJ may cause a further negative impact. This study highlights the possible need to include psychosocial and physical evaluations in the management process of MRONJ in cancer patients. |
| first_indexed | 2024-03-10T20:14:17Z |
| format | Article |
| id | doaj.art-37a8f53bca6242599ba0e4ad8ad6aa86 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T20:14:17Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-37a8f53bca6242599ba0e4ad8ad6aa862023-11-19T22:39:50ZengMDPI AGBiomedicines2227-90592020-04-01849510.3390/biomedicines8040095Does Medication-Related Osteonecrosis of the Jaw Influence the Quality of Life of Cancer Patients?Gianluca Tenore0Ahmed Mohsen1Antonella Francesca Rossi2Gaspare Palaia3Federica Rocchetti4Andrea Cassoni5Valentino Valentini6Livia Ottolenghi7Antonella Polimeni8Umberto Romeo9Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, ItalyThe aim of this study is to observe the influence of Medication-Related Osteonecrosis of the Jaw (MRONJ) on the physical and mental conditions of cancer patients using a Quality of Life (QoL) questionnaire during regular dental practice measures. Twenty cancer patients (8 males and 12 females) with established MRONJ were enrolled in the “MoMax” (Oral Medicine and Maxillofacial) project of the Department of Oral Sciences and Maxillofacial Surgery at “Sapienza” University of Rome, and were included in the study. The 12-item Short Form Survey was used to evaluate the QoL. Statistical analysis revealed a significant difference for Mental Component Summary (MCS) scores based on age (<i>p</i> = 0.018). The regression analysis revealed that the Physical Component Summary (PCS) scores were negatively influenced by the anti-resorptive medication duration (<i>p</i> = 0.031 and β = −1.137). No significant differences were observed with the other variables considered. The QoL of cancer patients is generally deteriorated and MRONJ may cause a further negative impact. This study highlights the possible need to include psychosocial and physical evaluations in the management process of MRONJ in cancer patients.https://www.mdpi.com/2227-9059/8/4/95bisphosphonatesMedication-Related Osteonecrosis of the Jawosteonecrosisquality of lifeSF-12 questionnaire |
| spellingShingle | Gianluca Tenore Ahmed Mohsen Antonella Francesca Rossi Gaspare Palaia Federica Rocchetti Andrea Cassoni Valentino Valentini Livia Ottolenghi Antonella Polimeni Umberto Romeo Does Medication-Related Osteonecrosis of the Jaw Influence the Quality of Life of Cancer Patients? Biomedicines bisphosphonates Medication-Related Osteonecrosis of the Jaw osteonecrosis quality of life SF-12 questionnaire |
| title | Does Medication-Related Osteonecrosis of the Jaw Influence the Quality of Life of Cancer Patients? |
| title_full | Does Medication-Related Osteonecrosis of the Jaw Influence the Quality of Life of Cancer Patients? |
| title_fullStr | Does Medication-Related Osteonecrosis of the Jaw Influence the Quality of Life of Cancer Patients? |
| title_full_unstemmed | Does Medication-Related Osteonecrosis of the Jaw Influence the Quality of Life of Cancer Patients? |
| title_short | Does Medication-Related Osteonecrosis of the Jaw Influence the Quality of Life of Cancer Patients? |
| title_sort | does medication related osteonecrosis of the jaw influence the quality of life of cancer patients |
| topic | bisphosphonates Medication-Related Osteonecrosis of the Jaw osteonecrosis quality of life SF-12 questionnaire |
| url | https://www.mdpi.com/2227-9059/8/4/95 |
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