Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study
Abstract Low hand grip strength (HGS) is associated with several conditions, but its value outside of the older adult population is unclear. We sought to identify the most salient factors associated with HGS from an extensive list of candidate variables while stratifying by age and sex. We used data...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-55978-7 |
| _version_ | 1797199454195941376 |
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| author | Kenneth A. Taylor Megan K. Carroll Sarah A. Short Adam P. Goode |
| author_facet | Kenneth A. Taylor Megan K. Carroll Sarah A. Short Adam P. Goode |
| author_sort | Kenneth A. Taylor |
| collection | DOAJ |
| description | Abstract Low hand grip strength (HGS) is associated with several conditions, but its value outside of the older adult population is unclear. We sought to identify the most salient factors associated with HGS from an extensive list of candidate variables while stratifying by age and sex. We used data from the initial visit from the Project Baseline Health Study (N = 2502) which captured detailed demographic, occupational, social, lifestyle, and clinical data. We applied MI-LASSO using group methods to determine variables most associated with HGS out of 175 candidate variables. We performed analyses separately for sex and age (< 65 vs. ≥ 65 years). Race was associated with HGS to varying degrees across groups. Osteoporosis and osteopenia were negatively associated with HGS in female study participants. Immune cell counts were negatively associated with HGS for male participants ≥ 65 (neutrophils) and female participants (≥ 65, monocytes; < 65, lymphocytes). Most findings were age and/or sex group-specific; few were common across all groups. Several of the variables associated with HGS in each group were novel, while others corroborate previous research. Our results support HGS as a useful indicator of a variety of clinical characteristics; however, its utility varies by age and sex. |
| first_indexed | 2024-04-24T07:16:00Z |
| format | Article |
| id | doaj.art-37ab0c7433b34b2fad58839716d09b3b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T07:16:00Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-37ab0c7433b34b2fad58839716d09b3b2024-04-21T11:17:57ZengNature PortfolioScientific Reports2045-23222024-04-0114111210.1038/s41598-024-55978-7Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health StudyKenneth A. Taylor0Megan K. Carroll1Sarah A. Short2Adam P. Goode3Department of Orthopaedic Surgery, Duke University School of MedicineVerily Life SciencesVerily Life SciencesDepartment of Orthopaedic Surgery, Duke University School of MedicineAbstract Low hand grip strength (HGS) is associated with several conditions, but its value outside of the older adult population is unclear. We sought to identify the most salient factors associated with HGS from an extensive list of candidate variables while stratifying by age and sex. We used data from the initial visit from the Project Baseline Health Study (N = 2502) which captured detailed demographic, occupational, social, lifestyle, and clinical data. We applied MI-LASSO using group methods to determine variables most associated with HGS out of 175 candidate variables. We performed analyses separately for sex and age (< 65 vs. ≥ 65 years). Race was associated with HGS to varying degrees across groups. Osteoporosis and osteopenia were negatively associated with HGS in female study participants. Immune cell counts were negatively associated with HGS for male participants ≥ 65 (neutrophils) and female participants (≥ 65, monocytes; < 65, lymphocytes). Most findings were age and/or sex group-specific; few were common across all groups. Several of the variables associated with HGS in each group were novel, while others corroborate previous research. Our results support HGS as a useful indicator of a variety of clinical characteristics; however, its utility varies by age and sex.https://doi.org/10.1038/s41598-024-55978-7 |
| spellingShingle | Kenneth A. Taylor Megan K. Carroll Sarah A. Short Adam P. Goode Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study Scientific Reports |
| title | Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study |
| title_full | Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study |
| title_fullStr | Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study |
| title_full_unstemmed | Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study |
| title_short | Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study |
| title_sort | identifying characteristics and clinical conditions associated with hand grip strength in adults the project baseline health study |
| url | https://doi.org/10.1038/s41598-024-55978-7 |
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