Greater interruption of visual processing and memory encoding by visceral than somatic pain in healthy volunteers – An fMRI study
Visceral pain is regarded as more salient than somatic pain. It has greater affective and emotional components, i.e., it elicits higher levels of pain-related fear and is perceived as more unpleasant than somatic pain. In this fMRI study, we examined the neural effects of painful visceral as compare...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922004529 |
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| author | Katharina Schmidt Julian Kleine-Borgmann Katrin Scharmach Diana Müssgens Sigrid Elsenbruch Ulrike Bingel Katarina Forkmann |
| author_facet | Katharina Schmidt Julian Kleine-Borgmann Katrin Scharmach Diana Müssgens Sigrid Elsenbruch Ulrike Bingel Katarina Forkmann |
| author_sort | Katharina Schmidt |
| collection | DOAJ |
| description | Visceral pain is regarded as more salient than somatic pain. It has greater affective and emotional components, i.e., it elicits higher levels of pain-related fear and is perceived as more unpleasant than somatic pain. In this fMRI study, we examined the neural effects of painful visceral as compared to painful somatic stimulation on visual processing and memory encoding in a visual categorization and surprise recognition task in healthy volunteers. During the categorization task, participants received either rectal distensions or heat stimuli applied to the forearm, with stimuli being individually matched for unpleasantness. Behaviorally, visceral pain reduced memory encoding as compared to somatic pain (Kleine-Borgmann et al., 2021). Imaging analyses now revealed that visceral pain was associated with reduced activity (i.e., greater pain-related interruption) in neural areas typically involved in visual processing and memory encoding. These include the parahippocampal gyrus, fusiform gyrus, striatum, occipital cortex, insula, and the amygdala. Moreover, reduced engagement of the lateral occipital complex during visual categorization under visceral pain was associated with higher visceral pain-related fear. These findings obtained in healthy volunteers shed light on the neural circuitry underlying the interruptive effect of visceral pain and pave the way for future studies in patient samples. |
| first_indexed | 2024-04-12T17:14:44Z |
| format | Article |
| id | doaj.art-37ab0f33943745bbbaf72c2dd2cffd13 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-12T17:14:44Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-37ab0f33943745bbbaf72c2dd2cffd132022-12-22T03:23:41ZengElsevierNeuroImage1095-95722022-08-01257119333Greater interruption of visual processing and memory encoding by visceral than somatic pain in healthy volunteers – An fMRI studyKatharina Schmidt0Julian Kleine-Borgmann1Katrin Scharmach2Diana Müssgens3Sigrid Elsenbruch4Ulrike Bingel5Katarina Forkmann6Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstrasse 55, Essen 45147, Germany; Corresponding author.Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstrasse 55, Essen 45147, GermanyDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstrasse 55, Essen 45147, GermanyDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstrasse 55, Essen 45147, GermanyDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstrasse 55, Essen 45147, Germany; Department of Medical Psychology and Medical Sociology, Ruhr University Bochum, GermanyDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstrasse 55, Essen 45147, GermanyDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstrasse 55, Essen 45147, GermanyVisceral pain is regarded as more salient than somatic pain. It has greater affective and emotional components, i.e., it elicits higher levels of pain-related fear and is perceived as more unpleasant than somatic pain. In this fMRI study, we examined the neural effects of painful visceral as compared to painful somatic stimulation on visual processing and memory encoding in a visual categorization and surprise recognition task in healthy volunteers. During the categorization task, participants received either rectal distensions or heat stimuli applied to the forearm, with stimuli being individually matched for unpleasantness. Behaviorally, visceral pain reduced memory encoding as compared to somatic pain (Kleine-Borgmann et al., 2021). Imaging analyses now revealed that visceral pain was associated with reduced activity (i.e., greater pain-related interruption) in neural areas typically involved in visual processing and memory encoding. These include the parahippocampal gyrus, fusiform gyrus, striatum, occipital cortex, insula, and the amygdala. Moreover, reduced engagement of the lateral occipital complex during visual categorization under visceral pain was associated with higher visceral pain-related fear. These findings obtained in healthy volunteers shed light on the neural circuitry underlying the interruptive effect of visceral pain and pave the way for future studies in patient samples.http://www.sciencedirect.com/science/article/pii/S1053811922004529Visceral painSomatic painHeat painInterruptive functionfMRIMemory encoding |
| spellingShingle | Katharina Schmidt Julian Kleine-Borgmann Katrin Scharmach Diana Müssgens Sigrid Elsenbruch Ulrike Bingel Katarina Forkmann Greater interruption of visual processing and memory encoding by visceral than somatic pain in healthy volunteers – An fMRI study NeuroImage Visceral pain Somatic pain Heat pain Interruptive function fMRI Memory encoding |
| title | Greater interruption of visual processing and memory encoding by visceral than somatic pain in healthy volunteers – An fMRI study |
| title_full | Greater interruption of visual processing and memory encoding by visceral than somatic pain in healthy volunteers – An fMRI study |
| title_fullStr | Greater interruption of visual processing and memory encoding by visceral than somatic pain in healthy volunteers – An fMRI study |
| title_full_unstemmed | Greater interruption of visual processing and memory encoding by visceral than somatic pain in healthy volunteers – An fMRI study |
| title_short | Greater interruption of visual processing and memory encoding by visceral than somatic pain in healthy volunteers – An fMRI study |
| title_sort | greater interruption of visual processing and memory encoding by visceral than somatic pain in healthy volunteers an fmri study |
| topic | Visceral pain Somatic pain Heat pain Interruptive function fMRI Memory encoding |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922004529 |
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