Lens Fibrosis: Understanding the Dynamics of Cell Adhesion Signaling in Lens Epithelial-Mesenchymal Transition
Injury to the ocular lens perturbs cell-cell and cell-capsule/basement membrane interactions leading to a myriad of interconnected signaling events. These events include cell-adhesion and growth factor-mediated signaling pathways that can ultimately result in the induction and progression of epithel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.886053/full |
| _version_ | 1811253416226193408 |
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| author | Aftab Taiyab Judith West-Mays |
| author_facet | Aftab Taiyab Judith West-Mays |
| author_sort | Aftab Taiyab |
| collection | DOAJ |
| description | Injury to the ocular lens perturbs cell-cell and cell-capsule/basement membrane interactions leading to a myriad of interconnected signaling events. These events include cell-adhesion and growth factor-mediated signaling pathways that can ultimately result in the induction and progression of epithelial-mesenchymal transition (EMT) of lens epithelial cells and fibrosis. Since the lens is avascular, consisting of a single layer of epithelial cells on its anterior surface and encased in a matrix rich capsule, it is one of the most simple and desired systems to investigate injury-induced signaling pathways that contribute to EMT and fibrosis. In this review, we will discuss the role of key cell-adhesion and mechanotransduction related signaling pathways that regulate EMT and fibrosis in the lens. |
| first_indexed | 2024-04-12T16:49:42Z |
| format | Article |
| id | doaj.art-37ae82c7bf484a71bf7cf716cbb4fe4d |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T16:49:42Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-37ae82c7bf484a71bf7cf716cbb4fe4d2022-12-22T03:24:25ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-05-011010.3389/fcell.2022.886053886053Lens Fibrosis: Understanding the Dynamics of Cell Adhesion Signaling in Lens Epithelial-Mesenchymal TransitionAftab TaiyabJudith West-MaysInjury to the ocular lens perturbs cell-cell and cell-capsule/basement membrane interactions leading to a myriad of interconnected signaling events. These events include cell-adhesion and growth factor-mediated signaling pathways that can ultimately result in the induction and progression of epithelial-mesenchymal transition (EMT) of lens epithelial cells and fibrosis. Since the lens is avascular, consisting of a single layer of epithelial cells on its anterior surface and encased in a matrix rich capsule, it is one of the most simple and desired systems to investigate injury-induced signaling pathways that contribute to EMT and fibrosis. In this review, we will discuss the role of key cell-adhesion and mechanotransduction related signaling pathways that regulate EMT and fibrosis in the lens.https://www.frontiersin.org/articles/10.3389/fcell.2022.886053/fullocular lenstransforming growth factor βepithelial to mesenchymal transitionfibrosiscell adhesion |
| spellingShingle | Aftab Taiyab Judith West-Mays Lens Fibrosis: Understanding the Dynamics of Cell Adhesion Signaling in Lens Epithelial-Mesenchymal Transition Frontiers in Cell and Developmental Biology ocular lens transforming growth factor β epithelial to mesenchymal transition fibrosis cell adhesion |
| title | Lens Fibrosis: Understanding the Dynamics of Cell Adhesion Signaling in Lens Epithelial-Mesenchymal Transition |
| title_full | Lens Fibrosis: Understanding the Dynamics of Cell Adhesion Signaling in Lens Epithelial-Mesenchymal Transition |
| title_fullStr | Lens Fibrosis: Understanding the Dynamics of Cell Adhesion Signaling in Lens Epithelial-Mesenchymal Transition |
| title_full_unstemmed | Lens Fibrosis: Understanding the Dynamics of Cell Adhesion Signaling in Lens Epithelial-Mesenchymal Transition |
| title_short | Lens Fibrosis: Understanding the Dynamics of Cell Adhesion Signaling in Lens Epithelial-Mesenchymal Transition |
| title_sort | lens fibrosis understanding the dynamics of cell adhesion signaling in lens epithelial mesenchymal transition |
| topic | ocular lens transforming growth factor β epithelial to mesenchymal transition fibrosis cell adhesion |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.886053/full |
| work_keys_str_mv | AT aftabtaiyab lensfibrosisunderstandingthedynamicsofcelladhesionsignalinginlensepithelialmesenchymaltransition AT judithwestmays lensfibrosisunderstandingthedynamicsofcelladhesionsignalinginlensepithelialmesenchymaltransition |