Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair
Current treatments for full-thickness skin injuries are still unsatisfactory due to the lack of hierarchically stimulated dressings that can integrate the rapid hemostasis, inflammation regulation, and skin tissue remodeling into the one system instead of single-stage boosting. In this work, a multi...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-07-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23000312 |
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| author | Yidan Wang Meng luo Ting Li Chenxi Xie Sihua Li Bo Lei |
| author_facet | Yidan Wang Meng luo Ting Li Chenxi Xie Sihua Li Bo Lei |
| author_sort | Yidan Wang |
| collection | DOAJ |
| description | Current treatments for full-thickness skin injuries are still unsatisfactory due to the lack of hierarchically stimulated dressings that can integrate the rapid hemostasis, inflammation regulation, and skin tissue remodeling into the one system instead of single-stage boosting. In this work, a multilayer-structured bioactive glass nanopowder (BGN@PTE) is developed by coating the poly-tannic acid and ε-polylysine onto the BGN via facile layer-by-layer assembly as an integrative and multilevel dressing for the sequential management of wounds. In comparison to BGN and poly-tannic acid coated BGN, BGN@PTE exhibited the better hemostatic performance because of its multiple dependent approaches to induce the platelet adhesion/activation, red blood cells (RBCs) aggregation and fibrin network formation. Simultaneously, the bioactive ions from BGN facilitate the regulation of the inflammatory response while the poly-tannic acid and antibacterial ε-polylysine prevent the wound infection, promoting the wound healing during the inflammatory stage. In addition, BGN@PTE can serve as a reactive oxygen species scavenger, alleviate the oxidation stress in wound injury, induce the cell migration and angiogenesis, and promote the proliferation stage of wound repair. Therefore, BGN@PTE demonstrated the significantly higher wound repair capacity than the commercial bioglass dressing Dermlin™. This multifunctional BGN@PTE is a potentially valuable dressing for full-thickness wound management and may be expected to extend to the other wounds therapy. |
| first_indexed | 2024-04-09T21:56:09Z |
| format | Article |
| id | doaj.art-37af092eb818444d979d0d972726b50b |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-09T21:56:09Z |
| publishDate | 2023-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-37af092eb818444d979d0d972726b50b2023-03-24T04:23:09ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-07-0125319332Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repairYidan Wang0Meng luo1Ting Li2Chenxi Xie3Sihua Li4Bo Lei5Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710054, ChinaFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710054, ChinaFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710054, ChinaFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710054, ChinaFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710054, ChinaFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710054, China; State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710054, China; Instrument Analysis Center, Xi'an Jiaotong University, Xi'an, 710054, China; Corresponding author. Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.Current treatments for full-thickness skin injuries are still unsatisfactory due to the lack of hierarchically stimulated dressings that can integrate the rapid hemostasis, inflammation regulation, and skin tissue remodeling into the one system instead of single-stage boosting. In this work, a multilayer-structured bioactive glass nanopowder (BGN@PTE) is developed by coating the poly-tannic acid and ε-polylysine onto the BGN via facile layer-by-layer assembly as an integrative and multilevel dressing for the sequential management of wounds. In comparison to BGN and poly-tannic acid coated BGN, BGN@PTE exhibited the better hemostatic performance because of its multiple dependent approaches to induce the platelet adhesion/activation, red blood cells (RBCs) aggregation and fibrin network formation. Simultaneously, the bioactive ions from BGN facilitate the regulation of the inflammatory response while the poly-tannic acid and antibacterial ε-polylysine prevent the wound infection, promoting the wound healing during the inflammatory stage. In addition, BGN@PTE can serve as a reactive oxygen species scavenger, alleviate the oxidation stress in wound injury, induce the cell migration and angiogenesis, and promote the proliferation stage of wound repair. Therefore, BGN@PTE demonstrated the significantly higher wound repair capacity than the commercial bioglass dressing Dermlin™. This multifunctional BGN@PTE is a potentially valuable dressing for full-thickness wound management and may be expected to extend to the other wounds therapy.http://www.sciencedirect.com/science/article/pii/S2452199X23000312Bioactive materialsBioceramicsBioactive glass nanoparticlesWound repair |
| spellingShingle | Yidan Wang Meng luo Ting Li Chenxi Xie Sihua Li Bo Lei Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair Bioactive Materials Bioactive materials Bioceramics Bioactive glass nanoparticles Wound repair |
| title | Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair |
| title_full | Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair |
| title_fullStr | Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair |
| title_full_unstemmed | Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair |
| title_short | Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair |
| title_sort | multi layer structured bioactive glass nanopowder for multistage stimulated hemostasis and wound repair |
| topic | Bioactive materials Bioceramics Bioactive glass nanoparticles Wound repair |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23000312 |
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