Reassessing guidelines for heart failure
Significant progress has been made in the last few years in the management of heart failure. In particular several trials have given significant results. It has become apparent that heart failure may be prevented in some patients by treatment of risk factors such as coronary artery disease. Experien...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2004-03-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | http://jra.sagepub.com/content/5/1_suppl/28.full.pdf |
| _version_ | 1797284982591324160 |
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| author | Helmut Drexler Kai C Wollert |
| author_facet | Helmut Drexler Kai C Wollert |
| author_sort | Helmut Drexler |
| collection | DOAJ |
| description | Significant progress has been made in the last few years in the management of heart failure. In particular several trials have given significant results. It has become apparent that heart failure may be prevented in some patients by treatment of risk factors such as coronary artery disease. Experience with angiotensin-converting enzyme (ACE) inhibitors has shown that the survival and symptomatic benefits do last in the long term, and confirm that they are the first-line treatment in heart failure. The results of a number of trials using the angiotensin receptor blockers (ARBs) candesartan, valsartan and losartan are presented and discussed. There is also some experience now in the use of candesartan for patients with heart failure and preserved left ventricular systolic function. The COMET trial compared the β-blockers carvedilol and metoprolol tartrate, and suggests that there may be differences in clinical effect between β-blockers. The selective aldosterone receptor blocker eplerenone was evaluated in the EPHESUS trial in post-MI patients with signs of heart failure. Based on these clinical trials, heart failure guidelines are now being updated. |
| first_indexed | 2024-03-07T17:56:35Z |
| format | Article |
| id | doaj.art-37af5e7970cd4f029a5fca9a03031a21 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:56:35Z |
| publishDate | 2004-03-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-37af5e7970cd4f029a5fca9a03031a212024-03-02T12:04:41ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762004-03-0151_suppl283310.3317/JRAAS.2004.02210.3317_JRAAS.2004.022Reassessing guidelines for heart failureHelmut DrexlerKai C WollertSignificant progress has been made in the last few years in the management of heart failure. In particular several trials have given significant results. It has become apparent that heart failure may be prevented in some patients by treatment of risk factors such as coronary artery disease. Experience with angiotensin-converting enzyme (ACE) inhibitors has shown that the survival and symptomatic benefits do last in the long term, and confirm that they are the first-line treatment in heart failure. The results of a number of trials using the angiotensin receptor blockers (ARBs) candesartan, valsartan and losartan are presented and discussed. There is also some experience now in the use of candesartan for patients with heart failure and preserved left ventricular systolic function. The COMET trial compared the β-blockers carvedilol and metoprolol tartrate, and suggests that there may be differences in clinical effect between β-blockers. The selective aldosterone receptor blocker eplerenone was evaluated in the EPHESUS trial in post-MI patients with signs of heart failure. Based on these clinical trials, heart failure guidelines are now being updated.http://jra.sagepub.com/content/5/1_suppl/28.full.pdf |
| spellingShingle | Helmut Drexler Kai C Wollert Reassessing guidelines for heart failure Journal of the Renin-Angiotensin-Aldosterone System |
| title | Reassessing guidelines for heart failure |
| title_full | Reassessing guidelines for heart failure |
| title_fullStr | Reassessing guidelines for heart failure |
| title_full_unstemmed | Reassessing guidelines for heart failure |
| title_short | Reassessing guidelines for heart failure |
| title_sort | reassessing guidelines for heart failure |
| url | http://jra.sagepub.com/content/5/1_suppl/28.full.pdf |
| work_keys_str_mv | AT helmutdrexler reassessingguidelinesforheartfailure AT kaicwollert reassessingguidelinesforheartfailure |