Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer

Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer

Abstract Background Alternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently caused by somatic splice site mutations or somatic mutations of splicing factor genes. However, the majority of mis-splicing in cancers is unexp...

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Bibliographic Details
Main Authors: April Lo, Maria McSharry, Alice H. Berger
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Cancer
Subjects:
KRAS
Splicing
Lung cancer
Gene expression
Proteomics
Online Access:https://doi.org/10.1186/s12885-022-10311-1

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