MIL-68 (Ga) for the extraction of derivatized and non-derivatized parabens from healthcare products
Abstract This study was the first-ever attempt to apply MIL-68 (Ga) in developing an analytical method. The method extracts and preconcentrates some parabens from mouthwash and hydrating gel samples. The variable extraction parameters were optimized, and the figures of merit were documented. Avogadr...
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| Format: | Article |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48880-1 |
| _version_ | 1797415237267226624 |
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| author | Sakha Pezhhanfar Mir Ali Farajzadeh Mahdi Kheirkhah Ghaleh Seyed Abolfazl Hosseini-Yazdi Mohammad Reza Afshar Mogaddam |
| author_facet | Sakha Pezhhanfar Mir Ali Farajzadeh Mahdi Kheirkhah Ghaleh Seyed Abolfazl Hosseini-Yazdi Mohammad Reza Afshar Mogaddam |
| author_sort | Sakha Pezhhanfar |
| collection | DOAJ |
| description | Abstract This study was the first-ever attempt to apply MIL-68 (Ga) in developing an analytical method. The method extracts and preconcentrates some parabens from mouthwash and hydrating gel samples. The variable extraction parameters were optimized, and the figures of merit were documented. Avogadro software was used besides discussing intermolecular interactions to clarify the absorption process. ComplexGAPI software was also exploited to assess the greenness of the method. After the derivatization of the parabens using acetic anhydride in the presence of sodium carbonate, sodium chloride was added to the solution and vortexed to dissolve. A few milligrams of MIL-68 (Ga) were added into the solution and vortexed. Centrifugation separated the analyte-loaded absorbent, which was treated with mL volume of methanol through vortexing for desorption aim. A few microliters of 1,2-dibromoethane were merged with the methanolic phase and injected into a sodium chloride solution. One microliter of the extracted phase was injected into a gas chromatograph equipped with a flame ionization detector. High enrichment factors (200–330), reasonable extraction recoveries (40–66%), wide linear ranges (265–30,000 µg L−1), and appreciable coefficients of determination (0.996–0.999) were documented. The applicability of dispersive solid phase extraction for extracting polar analytes, imposing no additional step for performing derivatization, the capability of MIL-68 (Ga) for the absorption of both derivatized and non-derivatized parabens, the use of only 10 mg absorbent, and one-pot synthesis besides no high temperature or long reaction time in the sorbent provision are the highlights of the method. |
| first_indexed | 2024-03-09T05:44:55Z |
| format | Article |
| id | doaj.art-37b1b457c79e4f008285fac32dae8371 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T05:44:55Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-37b1b457c79e4f008285fac32dae83712023-12-03T12:21:29ZengNature PortfolioScientific Reports2045-23222023-12-0113111510.1038/s41598-023-48880-1MIL-68 (Ga) for the extraction of derivatized and non-derivatized parabens from healthcare productsSakha Pezhhanfar0Mir Ali Farajzadeh1Mahdi Kheirkhah Ghaleh2Seyed Abolfazl Hosseini-Yazdi3Mohammad Reza Afshar Mogaddam4Department of Analytical Chemistry, Faculty of Chemistry, University of TabrizDepartment of Analytical Chemistry, Faculty of Chemistry, University of TabrizDepartment of Analytical Chemistry, Faculty of Chemistry, University of TabrizDepartment of Inorganic Chemistry, Faculty of Chemistry, University of TabrizFood and Drug Safety Research Center, Tabriz University of Medical SciencesAbstract This study was the first-ever attempt to apply MIL-68 (Ga) in developing an analytical method. The method extracts and preconcentrates some parabens from mouthwash and hydrating gel samples. The variable extraction parameters were optimized, and the figures of merit were documented. Avogadro software was used besides discussing intermolecular interactions to clarify the absorption process. ComplexGAPI software was also exploited to assess the greenness of the method. After the derivatization of the parabens using acetic anhydride in the presence of sodium carbonate, sodium chloride was added to the solution and vortexed to dissolve. A few milligrams of MIL-68 (Ga) were added into the solution and vortexed. Centrifugation separated the analyte-loaded absorbent, which was treated with mL volume of methanol through vortexing for desorption aim. A few microliters of 1,2-dibromoethane were merged with the methanolic phase and injected into a sodium chloride solution. One microliter of the extracted phase was injected into a gas chromatograph equipped with a flame ionization detector. High enrichment factors (200–330), reasonable extraction recoveries (40–66%), wide linear ranges (265–30,000 µg L−1), and appreciable coefficients of determination (0.996–0.999) were documented. The applicability of dispersive solid phase extraction for extracting polar analytes, imposing no additional step for performing derivatization, the capability of MIL-68 (Ga) for the absorption of both derivatized and non-derivatized parabens, the use of only 10 mg absorbent, and one-pot synthesis besides no high temperature or long reaction time in the sorbent provision are the highlights of the method.https://doi.org/10.1038/s41598-023-48880-1 |
| spellingShingle | Sakha Pezhhanfar Mir Ali Farajzadeh Mahdi Kheirkhah Ghaleh Seyed Abolfazl Hosseini-Yazdi Mohammad Reza Afshar Mogaddam MIL-68 (Ga) for the extraction of derivatized and non-derivatized parabens from healthcare products Scientific Reports |
| title | MIL-68 (Ga) for the extraction of derivatized and non-derivatized parabens from healthcare products |
| title_full | MIL-68 (Ga) for the extraction of derivatized and non-derivatized parabens from healthcare products |
| title_fullStr | MIL-68 (Ga) for the extraction of derivatized and non-derivatized parabens from healthcare products |
| title_full_unstemmed | MIL-68 (Ga) for the extraction of derivatized and non-derivatized parabens from healthcare products |
| title_short | MIL-68 (Ga) for the extraction of derivatized and non-derivatized parabens from healthcare products |
| title_sort | mil 68 ga for the extraction of derivatized and non derivatized parabens from healthcare products |
| url | https://doi.org/10.1038/s41598-023-48880-1 |
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