Metabolic labeling in middle-down proteomics allows for investigation of the dynamics of the histone code

Metabolic labeling in middle-down proteomics allows for investigation of the dynamics of the histone code

Abstract Background Middle-down mass spectrometry (MS), i.e., analysis of long (~50–60 aa) polypeptides, has become the method with the highest throughput and accuracy for the characterization of combinatorial histone posttranslational modifications (PTMs). The discovery of histone readers with mult...

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Bibliographic Details
Main Authors: Simone Sidoli, Congcong Lu, Mariel Coradin, Xiaoshi Wang, Kelly R. Karch, Chrystian Ruminowicz, Benjamin A. Garcia
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Epigenetics & Chromatin
Subjects:
Epigenetics
Histones
Mass spectrometry
Methylation
Middle-down
Posttranslational modifications
Online Access:http://link.springer.com/article/10.1186/s13072-017-0139-z

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