Antiviral activity of the dihydroquercetin during the Coxsackievirus В4 replication <i>in vitro</i>
A study of the antiviral activity of antioxidants against viral infections is believed to be essential for creating complex antiviral agents. Dihydroquercetin is considered as the most active antioxidant extracted from larix gmelinii. In this work, we present results of experiments of the antiviral...
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| Format: | Article |
| Language: | English |
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Central Research Institute for Epidemiology
2016-02-01
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| Series: | Вопросы вирусологии |
| Subjects: | |
| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/300/178 |
| _version_ | 1797782195478200320 |
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| author | A. V. Galochkina V. V. Zarubaev O. I. Kiselev V. A. Babkin L. A. Ostroukhova |
| author_facet | A. V. Galochkina V. V. Zarubaev O. I. Kiselev V. A. Babkin L. A. Ostroukhova |
| author_sort | A. V. Galochkina |
| collection | DOAJ |
| description | A study of the antiviral activity of antioxidants against viral infections is believed to be essential for creating complex antiviral agents. Dihydroquercetin is considered as the most active antioxidant extracted from larix gmelinii. In this work, we present results of experiments of the antiviral properties of dihydroquercetin against a member of the family picornaviridae – Coxsackievirus B4 in vitro. We have estimated that dihydroquercetin reduces viral titers at 100 µg/ml concentration as compared with control of virus. We have shown using the plaque assay that cpe of virus is reduced in the presence of dihydroquercetin at 100 µg/ml. Study of the phase of viral life cycle, in which dihydroquercetin acted, demonstrated that the highest efficacy of the antiviral therapy was reached at early stages of virus reproduction (1-3 hours post infection). These results show that dihydroquercetin has antiviral property against Coxsackievirus B4. This drug and other antioxidants can be tested as inhibitors of viral replication. |
| first_indexed | 2024-03-13T00:07:34Z |
| format | Article |
| id | doaj.art-37b54a78f6fa4a4191f248cd14510306 |
| institution | Directory Open Access Journal |
| issn | 0507-4088 2411-2097 |
| language | English |
| last_indexed | 2024-03-13T00:07:34Z |
| publishDate | 2016-02-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj.art-37b54a78f6fa4a4191f248cd145103062023-07-12T20:03:15ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972016-02-01611273110.18821/0507-4088-2016-61-1-27-31254Antiviral activity of the dihydroquercetin during the Coxsackievirus В4 replication <i>in vitro</i>A. V. Galochkina0V. V. Zarubaev1O. I. Kiselev2V. A. Babkin3L. A. Ostroukhova4Research Institute of InfluenzaResearch Institute of InfluenzaResearch Institute of InfluenzaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of SciencesA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of SciencesA study of the antiviral activity of antioxidants against viral infections is believed to be essential for creating complex antiviral agents. Dihydroquercetin is considered as the most active antioxidant extracted from larix gmelinii. In this work, we present results of experiments of the antiviral properties of dihydroquercetin against a member of the family picornaviridae – Coxsackievirus B4 in vitro. We have estimated that dihydroquercetin reduces viral titers at 100 µg/ml concentration as compared with control of virus. We have shown using the plaque assay that cpe of virus is reduced in the presence of dihydroquercetin at 100 µg/ml. Study of the phase of viral life cycle, in which dihydroquercetin acted, demonstrated that the highest efficacy of the antiviral therapy was reached at early stages of virus reproduction (1-3 hours post infection). These results show that dihydroquercetin has antiviral property against Coxsackievirus B4. This drug and other antioxidants can be tested as inhibitors of viral replication.https://virusjour.crie.ru/jour/article/viewFile/300/178enterovirusescoxsackieviruses b4dihydroquercetinantioxidantsantiviral agents |
| spellingShingle | A. V. Galochkina V. V. Zarubaev O. I. Kiselev V. A. Babkin L. A. Ostroukhova Antiviral activity of the dihydroquercetin during the Coxsackievirus В4 replication <i>in vitro</i> Вопросы вирусологии enteroviruses coxsackieviruses b4 dihydroquercetin antioxidants antiviral agents |
| title | Antiviral activity of the dihydroquercetin during the Coxsackievirus В4 replication <i>in vitro</i> |
| title_full | Antiviral activity of the dihydroquercetin during the Coxsackievirus В4 replication <i>in vitro</i> |
| title_fullStr | Antiviral activity of the dihydroquercetin during the Coxsackievirus В4 replication <i>in vitro</i> |
| title_full_unstemmed | Antiviral activity of the dihydroquercetin during the Coxsackievirus В4 replication <i>in vitro</i> |
| title_short | Antiviral activity of the dihydroquercetin during the Coxsackievirus В4 replication <i>in vitro</i> |
| title_sort | antiviral activity of the dihydroquercetin during the coxsackievirus в4 replication i in vitro i |
| topic | enteroviruses coxsackieviruses b4 dihydroquercetin antioxidants antiviral agents |
| url | https://virusjour.crie.ru/jour/article/viewFile/300/178 |
| work_keys_str_mv | AT avgalochkina antiviralactivityofthedihydroquercetinduringthecoxsackievirusv4replicationiinvitroi AT vvzarubaev antiviralactivityofthedihydroquercetinduringthecoxsackievirusv4replicationiinvitroi AT oikiselev antiviralactivityofthedihydroquercetinduringthecoxsackievirusv4replicationiinvitroi AT vababkin antiviralactivityofthedihydroquercetinduringthecoxsackievirusv4replicationiinvitroi AT laostroukhova antiviralactivityofthedihydroquercetinduringthecoxsackievirusv4replicationiinvitroi |