Calcium/calmodulin dependent protein kinase IV in trophoblast cells under insulin resistance: functional and metabolomic analyses

Calcium/calmodulin dependent protein kinase IV in trophoblast cells under insulin resistance: functional and metabolomic analyses

Abstract Background Insulin resistance (IR) is an important determinant of glucose metabolic disturbance and placental dysplasia in gestational diabetes mellitus (GDM). Calcium/calmodulin dependent protein kinase IV (CAMK4) improves insulin IR induced by a high-fat diet (HFD). The current study soug...

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Bibliographic Details
Main Authors: Ling Li, Li Li, Ying Shao, Runyu Du, Xiaoguang Shi, Yu Bai
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Molecular Medicine
Subjects:
Calcium/calmodulin dependent protein kinase IV
Gestational diabetes mellitus
Insulin resistance
Trophoblast cells
Autophagy
metabolomics
Online Access:https://doi.org/10.1186/s10020-023-00669-8

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