Circadian rhythms and renal pathophysiology
The reality of life in modern times is that our internal circadian rhythms are often out of alignment with the light/dark cycle of the external environment. This is known as circadian disruption, and a wealth of epidemiological evidence shows that it is associated with an increased risk for cardiova...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical Investigation
2022-02-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI148277 |
| _version_ | 1811334862863335424 |
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| author | Rajesh Mohandas Lauren G. Douma Yogesh Scindia Michelle L. Gumz |
| author_facet | Rajesh Mohandas Lauren G. Douma Yogesh Scindia Michelle L. Gumz |
| author_sort | Rajesh Mohandas |
| collection | DOAJ |
| description | The reality of life in modern times is that our internal circadian rhythms are often out of alignment with the light/dark cycle of the external environment. This is known as circadian disruption, and a wealth of epidemiological evidence shows that it is associated with an increased risk for cardiovascular disease. Cardiovascular disease remains the top cause of death in the United States, and kidney disease in particular is a tremendous public health burden that contributes to cardiovascular deaths. There is an urgent need for new treatments for kidney disease; circadian rhythm–based therapies may be of potential benefit. The goal of this Review is to summarize the existing data that demonstrate a connection between circadian rhythm disruption and renal impairment in humans. Specifically, we will focus on chronic kidney disease, lupus nephritis, hypertension, and aging. Importantly, the relationship between circadian dysfunction and pathophysiology is thought to be bidirectional. Here we discuss the gaps in our knowledge of the mechanisms underlying circadian dysfunction in diseases of the kidney. Finally, we provide a brief overview of potential circadian rhythm–based interventions that could provide benefit in renal disease. |
| first_indexed | 2024-04-13T17:15:38Z |
| format | Article |
| id | doaj.art-37b907a25de44c2b8424584eb170eabb |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-04-13T17:15:38Z |
| publishDate | 2022-02-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-37b907a25de44c2b8424584eb170eabb2022-12-22T02:38:08ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382022-02-011323Circadian rhythms and renal pathophysiologyRajesh MohandasLauren G. DoumaYogesh ScindiaMichelle L. GumzThe reality of life in modern times is that our internal circadian rhythms are often out of alignment with the light/dark cycle of the external environment. This is known as circadian disruption, and a wealth of epidemiological evidence shows that it is associated with an increased risk for cardiovascular disease. Cardiovascular disease remains the top cause of death in the United States, and kidney disease in particular is a tremendous public health burden that contributes to cardiovascular deaths. There is an urgent need for new treatments for kidney disease; circadian rhythm–based therapies may be of potential benefit. The goal of this Review is to summarize the existing data that demonstrate a connection between circadian rhythm disruption and renal impairment in humans. Specifically, we will focus on chronic kidney disease, lupus nephritis, hypertension, and aging. Importantly, the relationship between circadian dysfunction and pathophysiology is thought to be bidirectional. Here we discuss the gaps in our knowledge of the mechanisms underlying circadian dysfunction in diseases of the kidney. Finally, we provide a brief overview of potential circadian rhythm–based interventions that could provide benefit in renal disease.https://doi.org/10.1172/JCI148277 |
| spellingShingle | Rajesh Mohandas Lauren G. Douma Yogesh Scindia Michelle L. Gumz Circadian rhythms and renal pathophysiology The Journal of Clinical Investigation |
| title | Circadian rhythms and renal pathophysiology |
| title_full | Circadian rhythms and renal pathophysiology |
| title_fullStr | Circadian rhythms and renal pathophysiology |
| title_full_unstemmed | Circadian rhythms and renal pathophysiology |
| title_short | Circadian rhythms and renal pathophysiology |
| title_sort | circadian rhythms and renal pathophysiology |
| url | https://doi.org/10.1172/JCI148277 |
| work_keys_str_mv | AT rajeshmohandas circadianrhythmsandrenalpathophysiology AT laurengdouma circadianrhythmsandrenalpathophysiology AT yogeshscindia circadianrhythmsandrenalpathophysiology AT michellelgumz circadianrhythmsandrenalpathophysiology |