NRF2 Alters Mitochondrial Gene Expression in Neonate Mice Exposed to Hyperoxia

NRF2 Alters Mitochondrial Gene Expression in Neonate Mice Exposed to Hyperoxia

Approximately 1 in 10 newborns are born preterm and require supplemental oxygen (O<sub>2</sub>) in an extrauterine environment following birth. Supplemental O<sub>2</sub> can induce oxidative stress that can impair mitochondrial function, resulting in lung injury and increase...

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Bibliographic Details
Main Authors: Heather L. Vellers, Hye-Youn Cho, Wesley Gladwell, Kevin Gerrish, Janine H. Santos, Gaston Ofman, Laura Miller-DeGraff, T. Beth Mahler, Steven R. Kleeberger
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Antioxidants
Subjects:
mitochondrial sequencing
mtDNA copy number
heteroplasmy
mitochondrial function
NRF2
DNA lesions
Online Access:https://www.mdpi.com/2076-3921/11/4/760

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