Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes

Nanoelectrodes for measuring intracellular action potentials suffer from issues with success rate, signal strength and fabrication. Here, the authors report on a scalable technique which creates robust nanocrown electrodes with high success rates by electroporation and demonstrate the advance toward...

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Main Authors: Zeinab Jahed, Yang Yang, Ching-Ting Tsai, Ethan P. Foster, Allister F. McGuire, Huaxiao Yang, Aofei Liu, Csaba Forro, Zen Yan, Xin Jiang, Ming-Tao Zhao, Wei Zhang, Xiao Li, Thomas Li, Annalisa Pawlosky, Joseph C. Wu, Bianxiao Cui
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29726-2
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author Zeinab Jahed
Yang Yang
Ching-Ting Tsai
Ethan P. Foster
Allister F. McGuire
Huaxiao Yang
Aofei Liu
Csaba Forro
Zen Yan
Xin Jiang
Ming-Tao Zhao
Wei Zhang
Xiao Li
Thomas Li
Annalisa Pawlosky
Joseph C. Wu
Bianxiao Cui
author_facet Zeinab Jahed
Yang Yang
Ching-Ting Tsai
Ethan P. Foster
Allister F. McGuire
Huaxiao Yang
Aofei Liu
Csaba Forro
Zen Yan
Xin Jiang
Ming-Tao Zhao
Wei Zhang
Xiao Li
Thomas Li
Annalisa Pawlosky
Joseph C. Wu
Bianxiao Cui
author_sort Zeinab Jahed
collection DOAJ
description Nanoelectrodes for measuring intracellular action potentials suffer from issues with success rate, signal strength and fabrication. Here, the authors report on a scalable technique which creates robust nanocrown electrodes with high success rates by electroporation and demonstrate the advance towards preclinical drug evaluation.
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spelling doaj.art-37bb271c37e742a8b8014d1f28f5bb082022-12-22T02:35:39ZengNature PortfolioNature Communications2041-17232022-04-0113111410.1038/s41467-022-29726-2Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytesZeinab Jahed0Yang Yang1Ching-Ting Tsai2Ethan P. Foster3Allister F. McGuire4Huaxiao Yang5Aofei Liu6Csaba Forro7Zen Yan8Xin Jiang9Ming-Tao Zhao10Wei Zhang11Xiao Li12Thomas Li13Annalisa Pawlosky14Joseph C. Wu15Bianxiao Cui16Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford UniversityDepartment of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford UniversityDepartment of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford UniversityDepartment of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford UniversityDepartment of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford UniversityStanford Cardiovascular Institute, Stanford UniversityDepartment of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford UniversityDepartment of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford UniversityCyion Technologies, LLCCyion Technologies, LLCStanford Cardiovascular Institute, Stanford UniversityDepartment of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford UniversityDepartment of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford UniversityDepartment of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford UniversityGoogle Accelerated Sciences, Google LLCStanford Cardiovascular Institute, Stanford UniversityDepartment of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford UniversityNanoelectrodes for measuring intracellular action potentials suffer from issues with success rate, signal strength and fabrication. Here, the authors report on a scalable technique which creates robust nanocrown electrodes with high success rates by electroporation and demonstrate the advance towards preclinical drug evaluation.https://doi.org/10.1038/s41467-022-29726-2
spellingShingle Zeinab Jahed
Yang Yang
Ching-Ting Tsai
Ethan P. Foster
Allister F. McGuire
Huaxiao Yang
Aofei Liu
Csaba Forro
Zen Yan
Xin Jiang
Ming-Tao Zhao
Wei Zhang
Xiao Li
Thomas Li
Annalisa Pawlosky
Joseph C. Wu
Bianxiao Cui
Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes
Nature Communications
title Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes
title_full Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes
title_fullStr Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes
title_full_unstemmed Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes
title_short Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes
title_sort nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes
url https://doi.org/10.1038/s41467-022-29726-2
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