Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk.
BACKGROUND: Emerging evidence suggests that single nucleotide polymorphisms (SNPs) in microRNA-coding genes may participate in the pathogenesis of lung cancer by altering the expression of tumor-related microRNAs. Several studies were investigated in recent years to evaluate the association between...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3625214?pdf=render |
| _version_ | 1818535787037196288 |
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| author | Zhengrong Yuan Xu Zeng Dan Yang Weilu Wang Zhihua Liu |
| author_facet | Zhengrong Yuan Xu Zeng Dan Yang Weilu Wang Zhihua Liu |
| author_sort | Zhengrong Yuan |
| collection | DOAJ |
| description | BACKGROUND: Emerging evidence suggests that single nucleotide polymorphisms (SNPs) in microRNA-coding genes may participate in the pathogenesis of lung cancer by altering the expression of tumor-related microRNAs. Several studies were investigated in recent years to evaluate the association between hsa-miR-196a2 rs11614913 polymorphism and increased/decreased lung cancer risk. In the present study, we performed a meta-analysis to systematically summarize the possible association. METHODOLOGY/PRINCIPAL FINDINGS: We performed a meta-analysis of 4 case-control studies that included 2219 lung-cancer cases and 2232 cancer-free controls. We evaluated the strength of the association using odds ratios (ORs) with 95% confidence intervals (CIs). In the overall analysis, it was found that the rs11614913 polymorphism significantly elevated the risk of lung cancer (CC versus (vs.) TT OR = 1.26, 95% CI 1.07-1.49, P = 0.007; CC/CT vs. TT: OR = 1.13, 95% CI 0.98-1.29, P = 0.007; C vs. T: OR = 1.12, 95% CI 1.03-1.22, P = 0.008). In the subgroup analysis by ethnicity, statistically significantly increased cancer risk was found among Asians (CC vs. TT: OR = 1.30, 95% CI 1.10-1.54, P = 0.003; CT vs. TT: OR = 1.16, 95% CI 1.01-1.34, P = 0.039; CC vs. CT/TT: OR = 1.21, 95% CI 1.04-1.41, P = 0.012; C vs. T: OR = 1.14, 95% CI 1.05-1.25, P = 0.002). For Europeans, a significant association with lung cancer risk was found in recessive model (CC vs. CT/TT: OR = 0.63, 95% CI 0.40-0.98, P = 0.040). No publication bias was found in this study. CONCLUSIONS/SIGNIFICANCE: Our meta-analysis suggests that the rs11614913 polymorphism is significant associated with the increased risk of lung cancer, especially in Asians. Besides, the C allele of rs11614913 polymorphism may contribute to increased lung cancer risk. |
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| id | doaj.art-37bb7d02a0364c6e8c1906359e402616 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T18:29:34Z |
| publishDate | 2013-01-01 |
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| spelling | doaj.art-37bb7d02a0364c6e8c1906359e4026162022-12-22T00:54:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6104710.1371/journal.pone.0061047Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk.Zhengrong YuanXu ZengDan YangWeilu WangZhihua LiuBACKGROUND: Emerging evidence suggests that single nucleotide polymorphisms (SNPs) in microRNA-coding genes may participate in the pathogenesis of lung cancer by altering the expression of tumor-related microRNAs. Several studies were investigated in recent years to evaluate the association between hsa-miR-196a2 rs11614913 polymorphism and increased/decreased lung cancer risk. In the present study, we performed a meta-analysis to systematically summarize the possible association. METHODOLOGY/PRINCIPAL FINDINGS: We performed a meta-analysis of 4 case-control studies that included 2219 lung-cancer cases and 2232 cancer-free controls. We evaluated the strength of the association using odds ratios (ORs) with 95% confidence intervals (CIs). In the overall analysis, it was found that the rs11614913 polymorphism significantly elevated the risk of lung cancer (CC versus (vs.) TT OR = 1.26, 95% CI 1.07-1.49, P = 0.007; CC/CT vs. TT: OR = 1.13, 95% CI 0.98-1.29, P = 0.007; C vs. T: OR = 1.12, 95% CI 1.03-1.22, P = 0.008). In the subgroup analysis by ethnicity, statistically significantly increased cancer risk was found among Asians (CC vs. TT: OR = 1.30, 95% CI 1.10-1.54, P = 0.003; CT vs. TT: OR = 1.16, 95% CI 1.01-1.34, P = 0.039; CC vs. CT/TT: OR = 1.21, 95% CI 1.04-1.41, P = 0.012; C vs. T: OR = 1.14, 95% CI 1.05-1.25, P = 0.002). For Europeans, a significant association with lung cancer risk was found in recessive model (CC vs. CT/TT: OR = 0.63, 95% CI 0.40-0.98, P = 0.040). No publication bias was found in this study. CONCLUSIONS/SIGNIFICANCE: Our meta-analysis suggests that the rs11614913 polymorphism is significant associated with the increased risk of lung cancer, especially in Asians. Besides, the C allele of rs11614913 polymorphism may contribute to increased lung cancer risk.http://europepmc.org/articles/PMC3625214?pdf=render |
| spellingShingle | Zhengrong Yuan Xu Zeng Dan Yang Weilu Wang Zhihua Liu Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk. PLoS ONE |
| title | Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk. |
| title_full | Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk. |
| title_fullStr | Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk. |
| title_full_unstemmed | Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk. |
| title_short | Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk. |
| title_sort | effects of common polymorphism rs11614913 in hsa mir 196a2 on lung cancer risk |
| url | http://europepmc.org/articles/PMC3625214?pdf=render |
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