The liver-derived exosomes stimulate insulin gene expression in pancreatic beta cells under condition of insulin resistance

The liver-derived exosomes stimulate insulin gene expression in pancreatic beta cells under condition of insulin resistance

IntroductionAn insufficient functional beta cell mass is a core pathological hallmark of type 2 diabetes (T2D). Despite the availability of several effective pharmaceuticals for diabetes management, there is an urgent need for novel medications to protect pancreatic beta cells under diabetic conditi...

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Bibliographic Details
Main Authors: Azam Mahmoudi-Aznaveh, Gholamreza Tavoosidana, Hossein Najmabadi, Zahra Azizi, Amin Ardestani
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Endocrinology
Subjects:
type 2 diabetes
pancreatic islet
beta cell
liver
organ cross-talk
exosome
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1303930/full

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