Comparative characteristics of methods of allergological examination for house dust mite allergy in children with bronchial asthma and allergic rhinitis
Objective. To determine the diagnostic significance of methods of allergological diagnostics: skin prick tests (SPT), quantitative determination of specific immunoglobulin E (sIgE) and nasal provocative test (NPT) in children with allergy to house dust mites (HDM) diagnosed with allergic rhinitis (A...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Association of Paediatric Allergists and Immunologists of Russia (APAIR)
2023-07-01
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| Series: | Аллергология и Иммунология в Педиатрии |
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| Online Access: | https://adair.elpub.ru/jour/article/view/65 |
| _version_ | 1797768053358854144 |
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| author | O. V. Trusova A. V. Kamaev N. L. Lyashenko I. V. Makarova N. B. Platonova |
| author_facet | O. V. Trusova A. V. Kamaev N. L. Lyashenko I. V. Makarova N. B. Platonova |
| author_sort | O. V. Trusova |
| collection | DOAJ |
| description | Objective. To determine the diagnostic significance of methods of allergological diagnostics: skin prick tests (SPT), quantitative determination of specific immunoglobulin E (sIgE) and nasal provocative test (NPT) in children with allergy to house dust mites (HDM) diagnosed with allergic rhinitis (AR) or AR in combination with asthma. Methods. Patients underwent a targeted history taking for possible domestic sensitization, SPT with HDM allergens, NPT with HDM, and sIgE to HDM allergens was determined by the ImmunoCAP method. Results. The statistical processing group included 109 children (67 boys, 42 girls, aged 5 to 17,9 years (mean age 8,9 ± 2,52 years)), in whom sensitization to HDM was confirmed by at least one of the methods used in the study. A higher sensitivity of SPT then of sIgE was determined (96,3 % and 81,6 %, respectively). According to SPT and sIgE results, sensitization to both types of mites (D. pteronyssinus and D. farinae) is more common than isolated. Coincidence of positive results of SPT and sIgE was obtained in 84 cases (77,1 %). Conclusion. SPT can be considered as the first line of investigation. The use of a complex of examination methods is necessary to determine the role of sensitization to HDM, if NPT is taken as the «gold» standard of diagnosis. |
| first_indexed | 2024-03-12T20:48:59Z |
| format | Article |
| id | doaj.art-37be17a8a5264bb7a181d43f9239940f |
| institution | Directory Open Access Journal |
| issn | 2500-1175 2712-7958 |
| language | Russian |
| last_indexed | 2024-03-12T20:48:59Z |
| publishDate | 2023-07-01 |
| publisher | Association of Paediatric Allergists and Immunologists of Russia (APAIR) |
| record_format | Article |
| series | Аллергология и Иммунология в Педиатрии |
| spelling | doaj.art-37be17a8a5264bb7a181d43f9239940f2023-08-01T07:30:45ZrusAssociation of Paediatric Allergists and Immunologists of Russia (APAIR)Аллергология и Иммунология в Педиатрии2500-11752712-79582023-07-0102192610.53529/2500-1175-2022-2-19-2661Comparative characteristics of methods of allergological examination for house dust mite allergy in children with bronchial asthma and allergic rhinitisO. V. Trusova0A. V. Kamaev1N. L. Lyashenko2I. V. Makarova3N. B. Platonova4Federal State Budgetary Educational Institution of Higher Education First St. Petersburg State Medical University named after Academician I. P. Pavlov of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education First St. Petersburg State Medical University named after Academician I. P. Pavlov of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education First St. Petersburg State Medical University named after Academician I. P. Pavlov of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education First St. Petersburg State Medical University named after Academician I. P. Pavlov of the Ministry of Health of the Russian FederationSt. Petersburg «Children’s City Multidisciplinary Clinical Specialized Center for High Medical Technologies»Objective. To determine the diagnostic significance of methods of allergological diagnostics: skin prick tests (SPT), quantitative determination of specific immunoglobulin E (sIgE) and nasal provocative test (NPT) in children with allergy to house dust mites (HDM) diagnosed with allergic rhinitis (AR) or AR in combination with asthma. Methods. Patients underwent a targeted history taking for possible domestic sensitization, SPT with HDM allergens, NPT with HDM, and sIgE to HDM allergens was determined by the ImmunoCAP method. Results. The statistical processing group included 109 children (67 boys, 42 girls, aged 5 to 17,9 years (mean age 8,9 ± 2,52 years)), in whom sensitization to HDM was confirmed by at least one of the methods used in the study. A higher sensitivity of SPT then of sIgE was determined (96,3 % and 81,6 %, respectively). According to SPT and sIgE results, sensitization to both types of mites (D. pteronyssinus and D. farinae) is more common than isolated. Coincidence of positive results of SPT and sIgE was obtained in 84 cases (77,1 %). Conclusion. SPT can be considered as the first line of investigation. The use of a complex of examination methods is necessary to determine the role of sensitization to HDM, if NPT is taken as the «gold» standard of diagnosis.https://adair.elpub.ru/jour/article/view/65allergic rhinitisbronchial asthmachildrenhouse dust mitesallergological diagnostics |
| spellingShingle | O. V. Trusova A. V. Kamaev N. L. Lyashenko I. V. Makarova N. B. Platonova Comparative characteristics of methods of allergological examination for house dust mite allergy in children with bronchial asthma and allergic rhinitis Аллергология и Иммунология в Педиатрии allergic rhinitis bronchial asthma children house dust mites allergological diagnostics |
| title | Comparative characteristics of methods of allergological examination for house dust mite allergy in children with bronchial asthma and allergic rhinitis |
| title_full | Comparative characteristics of methods of allergological examination for house dust mite allergy in children with bronchial asthma and allergic rhinitis |
| title_fullStr | Comparative characteristics of methods of allergological examination for house dust mite allergy in children with bronchial asthma and allergic rhinitis |
| title_full_unstemmed | Comparative characteristics of methods of allergological examination for house dust mite allergy in children with bronchial asthma and allergic rhinitis |
| title_short | Comparative characteristics of methods of allergological examination for house dust mite allergy in children with bronchial asthma and allergic rhinitis |
| title_sort | comparative characteristics of methods of allergological examination for house dust mite allergy in children with bronchial asthma and allergic rhinitis |
| topic | allergic rhinitis bronchial asthma children house dust mites allergological diagnostics |
| url | https://adair.elpub.ru/jour/article/view/65 |
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