Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis
Abstract Objective We aimed to provide a reference based on evidence for an individualized clinical medication of high-dose methotrexate (HD-MTX) in osteosarcoma patients by evaluating the effect of gene polymorphism on adverse reactions of HD-MTX usage. Methods Several databases were combed for res...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-023-03287-0 |
| _version_ | 1797355704672059392 |
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| author | Ben Liu Gang Liu Binbin Liu Yao Guo Ningning Peng Tiejun Li |
| author_facet | Ben Liu Gang Liu Binbin Liu Yao Guo Ningning Peng Tiejun Li |
| author_sort | Ben Liu |
| collection | DOAJ |
| description | Abstract Objective We aimed to provide a reference based on evidence for an individualized clinical medication of high-dose methotrexate (HD-MTX) in osteosarcoma patients by evaluating the effect of gene polymorphism on adverse reactions of HD-MTX usage. Methods Several databases were combed for research on the association between gene polymorphisms and adverse reactions to HD-MTX up to January 2023. A meta-analysis and/or descriptive analysis on the incidence of HD-MTX-related adverse reactions were conducted by using clinical studies meeting inclusion criteria. Results Twelve studies involving 889 patients were included. There were 8, 6, 5, and 4 studies related to MTHFR C677T, MTHFR A1298C, RFC1 G80A, and MDR1 C3435T polymorphisms, respectively. The results of the meta-analysis showed that the MTHFR C677T polymorphism was associated with G3-4 hepatotoxicity, G3-4 nephrotoxicity, G3-4 gastrointestinal toxicity, and G3-4 mucositis under the recessive genetic model (MM vs. Mm/mm). Limited research showed that MTHFR C677T was associated with G3-4 nephrotoxicity in the allelic genetic model (M vs. m). MTHFR A1298C polymorphism was associated with a decreased risk of adverse reactions to HD-MTX usage, without statistical significance. This review's descriptive analysis showed no significant correlation between the RFC1 G80A, and MDR1 C3435T polymorphism and adverse reactions of HD-MTX. Conclusion The MTHFR C677T mutation may enhance the risk of HD-MTX adverse reactions in osteosarcoma patients. Existing studies have not found a significant correlation between the MTHFR A1298C, RFC1 G80A, and MDR1 C3435T polymorphism and adverse reactions caused by HD-MTX. Lastly, this conclusion was limited because of few studies. |
| first_indexed | 2024-03-08T14:14:56Z |
| format | Article |
| id | doaj.art-37beea97d6b446338e49331a7749ed1b |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-03-08T14:14:56Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-37beea97d6b446338e49331a7749ed1b2024-01-14T12:25:27ZengBMCWorld Journal of Surgical Oncology1477-78192024-01-0122111010.1186/s12957-023-03287-0Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysisBen Liu0Gang Liu1Binbin Liu2Yao Guo3Ningning Peng4Tiejun Li5Fourth Department of Orthopedics, Cangzhou Central HospitalFourth Department of Orthopedics, Cangzhou Central HospitalFourth Department of Orthopedics, Cangzhou Central HospitalCentral Laboratory, Cangzhou Central HospitalFourth Department of Orthopedics, Cangzhou Central HospitalLegal Affairs Office, Cangzhou Central HospitalAbstract Objective We aimed to provide a reference based on evidence for an individualized clinical medication of high-dose methotrexate (HD-MTX) in osteosarcoma patients by evaluating the effect of gene polymorphism on adverse reactions of HD-MTX usage. Methods Several databases were combed for research on the association between gene polymorphisms and adverse reactions to HD-MTX up to January 2023. A meta-analysis and/or descriptive analysis on the incidence of HD-MTX-related adverse reactions were conducted by using clinical studies meeting inclusion criteria. Results Twelve studies involving 889 patients were included. There were 8, 6, 5, and 4 studies related to MTHFR C677T, MTHFR A1298C, RFC1 G80A, and MDR1 C3435T polymorphisms, respectively. The results of the meta-analysis showed that the MTHFR C677T polymorphism was associated with G3-4 hepatotoxicity, G3-4 nephrotoxicity, G3-4 gastrointestinal toxicity, and G3-4 mucositis under the recessive genetic model (MM vs. Mm/mm). Limited research showed that MTHFR C677T was associated with G3-4 nephrotoxicity in the allelic genetic model (M vs. m). MTHFR A1298C polymorphism was associated with a decreased risk of adverse reactions to HD-MTX usage, without statistical significance. This review's descriptive analysis showed no significant correlation between the RFC1 G80A, and MDR1 C3435T polymorphism and adverse reactions of HD-MTX. Conclusion The MTHFR C677T mutation may enhance the risk of HD-MTX adverse reactions in osteosarcoma patients. Existing studies have not found a significant correlation between the MTHFR A1298C, RFC1 G80A, and MDR1 C3435T polymorphism and adverse reactions caused by HD-MTX. Lastly, this conclusion was limited because of few studies.https://doi.org/10.1186/s12957-023-03287-0High-dose MethotrexateAdverse ReactionsOsteosarcomaGene PolymorphismMeta-analysis |
| spellingShingle | Ben Liu Gang Liu Binbin Liu Yao Guo Ningning Peng Tiejun Li Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis World Journal of Surgical Oncology High-dose Methotrexate Adverse Reactions Osteosarcoma Gene Polymorphism Meta-analysis |
| title | Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis |
| title_full | Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis |
| title_fullStr | Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis |
| title_full_unstemmed | Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis |
| title_short | Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis |
| title_sort | correlation between gene polymorphism and adverse reactions of high dose methotrexate in osteosarcoma patients a systematic review and meta analysis |
| topic | High-dose Methotrexate Adverse Reactions Osteosarcoma Gene Polymorphism Meta-analysis |
| url | https://doi.org/10.1186/s12957-023-03287-0 |
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