Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial
This study investigated the efficacy of intrauterine infusion of a chitosan solution (CHT) on uterine recovery in early postpartum dairy cows with or without endometritis, and their subsequent reproductive performance. In Experiment 1, cows with endometritis at 3 weeks postpartum were administered C...
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MDPI AG
2021-01-01
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| Online Access: | https://www.mdpi.com/2076-2615/11/1/197 |
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| author | Hiroaki Okawa Missaka M.P. Wijayagunawardane Peter L.A.M. Vos Osamu Yamato Masayasu Taniguchi Mitsuhiro Takagi |
| author_facet | Hiroaki Okawa Missaka M.P. Wijayagunawardane Peter L.A.M. Vos Osamu Yamato Masayasu Taniguchi Mitsuhiro Takagi |
| author_sort | Hiroaki Okawa |
| collection | DOAJ |
| description | This study investigated the efficacy of intrauterine infusion of a chitosan solution (CHT) on uterine recovery in early postpartum dairy cows with or without endometritis, and their subsequent reproductive performance. In Experiment 1, cows with endometritis at 3 weeks postpartum were administered CHT (n = 5) and prostaglandin F<sub>2α</sub> (PGF<sub>2α</sub>) (n = 4). Untreated cows (n = 7) served as the control group. In Experiment 2, 18 cows with a normally recovered uterus at the fresh cow check (mean, 35 days postpartum) were assigned to the CHT (n = 10) and control (n = 8) groups, and intrauterine infusion was conducted in the CHT group. Overall, in Experiment 1, the percentage of polymorphonuclear leukocytes significantly declined in the CHT group (32.3 ± 10.2 to 5.5 ± 2.4, <i>p</i> < 0.05) from week 3 to week 5, but no decline occurred in the PGF<sub>2α</sub> and control groups. In Experiment 2, the CHT and control groups showed no significant differences in reproductive parameters, suggesting the absence of adverse effects of CHT on fertility. These results suggest that intrauterine infusion of CHT in the early postpartum period effectively accelerates uterine recovery from endometritis and might be a suitable replacement for PGF<sub>2α</sub> administration. |
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| last_indexed | 2024-03-09T04:39:51Z |
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| spelling | doaj.art-37bf839545534524a888ed166d9afc232023-12-03T13:21:41ZengMDPI AGAnimals2076-26152021-01-0111119710.3390/ani11010197Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field TrialHiroaki Okawa0Missaka M.P. Wijayagunawardane1Peter L.A.M. Vos2Osamu Yamato3Masayasu Taniguchi4Mitsuhiro Takagi5United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, JapanDepartment of Animal Science, University of Peradeniya, Peradeniya 20400, Sri LankaDepartment Population Health Sciences, Farm Animal Health, Section Reproduction, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The NetherlandsUnited Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, JapanUnited Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, JapanUnited Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, JapanThis study investigated the efficacy of intrauterine infusion of a chitosan solution (CHT) on uterine recovery in early postpartum dairy cows with or without endometritis, and their subsequent reproductive performance. In Experiment 1, cows with endometritis at 3 weeks postpartum were administered CHT (n = 5) and prostaglandin F<sub>2α</sub> (PGF<sub>2α</sub>) (n = 4). Untreated cows (n = 7) served as the control group. In Experiment 2, 18 cows with a normally recovered uterus at the fresh cow check (mean, 35 days postpartum) were assigned to the CHT (n = 10) and control (n = 8) groups, and intrauterine infusion was conducted in the CHT group. Overall, in Experiment 1, the percentage of polymorphonuclear leukocytes significantly declined in the CHT group (32.3 ± 10.2 to 5.5 ± 2.4, <i>p</i> < 0.05) from week 3 to week 5, but no decline occurred in the PGF<sub>2α</sub> and control groups. In Experiment 2, the CHT and control groups showed no significant differences in reproductive parameters, suggesting the absence of adverse effects of CHT on fertility. These results suggest that intrauterine infusion of CHT in the early postpartum period effectively accelerates uterine recovery from endometritis and might be a suitable replacement for PGF<sub>2α</sub> administration.https://www.mdpi.com/2076-2615/11/1/197chitosandairy cowendometritispolymorphonuclear leukocytestreatment |
| spellingShingle | Hiroaki Okawa Missaka M.P. Wijayagunawardane Peter L.A.M. Vos Osamu Yamato Masayasu Taniguchi Mitsuhiro Takagi Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial Animals chitosan dairy cow endometritis polymorphonuclear leukocytes treatment |
| title | Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial |
| title_full | Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial |
| title_fullStr | Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial |
| title_full_unstemmed | Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial |
| title_short | Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial |
| title_sort | effects of intrauterine infusion of a chitosan solution on recovery and subsequent reproductive performance of early postpartum dairy cows with endometritis a pilot field trial |
| topic | chitosan dairy cow endometritis polymorphonuclear leukocytes treatment |
| url | https://www.mdpi.com/2076-2615/11/1/197 |
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