Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α
Golgi disassembly is required for mitosis and occurs by vesicle fusion suppression, although the mechanism is unclear. Here, Chang et al. show, with quantitative analyses and crystallography, that Importin-α regulates this process by blocking GM130-p115 interactions in a Ran pathway-independent way....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12207-4 |
| _version_ | 1819040305140203520 |
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| author | Chih-Chia Chang Ching-Jou Chen Cédric Grauffel Yu-Chung Pien Carmay Lim Su-Yi Tsai Kuo-Chiang Hsia |
| author_facet | Chih-Chia Chang Ching-Jou Chen Cédric Grauffel Yu-Chung Pien Carmay Lim Su-Yi Tsai Kuo-Chiang Hsia |
| author_sort | Chih-Chia Chang |
| collection | DOAJ |
| description | Golgi disassembly is required for mitosis and occurs by vesicle fusion suppression, although the mechanism is unclear. Here, Chang et al. show, with quantitative analyses and crystallography, that Importin-α regulates this process by blocking GM130-p115 interactions in a Ran pathway-independent way. |
| first_indexed | 2024-12-21T09:06:59Z |
| format | Article |
| id | doaj.art-37bfbade8b014be484b0d47ceba4a971 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:06:59Z |
| publishDate | 2019-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-37bfbade8b014be484b0d47ceba4a9712022-12-21T19:09:18ZengNature PortfolioNature Communications2041-17232019-09-0110111610.1038/s41467-019-12207-4Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-αChih-Chia Chang0Ching-Jou Chen1Cédric Grauffel2Yu-Chung Pien3Carmay Lim4Su-Yi Tsai5Kuo-Chiang Hsia6Institute of Molecular Biology, Academia SinicaDepartment of Life Science, National Taiwan UniversityInstitute of Biomedical Sciences, Academia SinicaDepartment of Life Science, National Taiwan UniversityInstitute of Biomedical Sciences, Academia SinicaDepartment of Life Science, National Taiwan UniversityInstitute of Molecular Biology, Academia SinicaGolgi disassembly is required for mitosis and occurs by vesicle fusion suppression, although the mechanism is unclear. Here, Chang et al. show, with quantitative analyses and crystallography, that Importin-α regulates this process by blocking GM130-p115 interactions in a Ran pathway-independent way.https://doi.org/10.1038/s41467-019-12207-4 |
| spellingShingle | Chih-Chia Chang Ching-Jou Chen Cédric Grauffel Yu-Chung Pien Carmay Lim Su-Yi Tsai Kuo-Chiang Hsia Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α Nature Communications |
| title | Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α |
| title_full | Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α |
| title_fullStr | Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α |
| title_full_unstemmed | Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α |
| title_short | Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α |
| title_sort | ran pathway independent regulation of mitotic golgi disassembly by importin α |
| url | https://doi.org/10.1038/s41467-019-12207-4 |
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