Kidney Biopsy and Immuno-Rheumatological Diseases: A Retrospective and Observational Study
Renal involvement is a common occurrence in patients with immuno-rheumatological diseases (IRDs). Several instances of glomerulonephritis (GN) occur in the setting of IRD and complicate the clinical course of an underlying condition. The aim of this study was to observe the spectrum of nephropathies...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/14/1/92 |
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| author | Antonietta Gigante Rosario Cianci Annalisa Villa Chiara Pellicano Konstantinos Giannakakis Edoardo Rosato Francesca Romana Spinelli Umberto Basile Cosimo Racco Elena Maria Di Virgilio Bruna Cerbelli Fabrizio Conti |
| author_facet | Antonietta Gigante Rosario Cianci Annalisa Villa Chiara Pellicano Konstantinos Giannakakis Edoardo Rosato Francesca Romana Spinelli Umberto Basile Cosimo Racco Elena Maria Di Virgilio Bruna Cerbelli Fabrizio Conti |
| author_sort | Antonietta Gigante |
| collection | DOAJ |
| description | Renal involvement is a common occurrence in patients with immuno-rheumatological diseases (IRDs). Several instances of glomerulonephritis (GN) occur in the setting of IRD and complicate the clinical course of an underlying condition. The aim of this study was to observe the spectrum of nephropathies according to age, kidney function, history of IRD at the time of biopsy, and histopathological kidney diagnosis. We evaluated data relating to 699 consecutive kidney native biopsies (female 52.1%) with a median age of 48 years (IQR 34–62) performed in adult patients collected over 15 years. The study population was divided into three groups: patients with kidney histological findings correlated to underlying IRD (Group 1), patients with kidney histological findings not correlated to underlying IRD (Group 2), and patients with kidney histological findings compatible with “de novo” IRD (absent in personal medical history) (Group 3). Kidney involvement related to IRD was found in 25.2% of patients. Group 1 was mostly represented by lupus nephritis (76.6%), with a younger age than Group 3 (<i>p</i> < 0.001) and by a higher percentage of females than other groups (<i>p</i> < 0.001). Group 3 was the most represented by microscopic polyangiitis (50.8%) when compared with the other two groups (<i>p</i> < 0.001). Acute nephritic syndrome (<i>p</i> < 0.001), acute kidney injury (AKI), and abnormal urinalysis (<i>p</i> < 0.001) were more represented in Group 3 than the other groups. In conclusion, IRDs are characterized by different clinical presentations and heterogeneous histological findings. Kidney biopsy remains fundamental to achieving the correct diagnosis and starting targeted therapy. |
| first_indexed | 2024-03-08T10:45:07Z |
| format | Article |
| id | doaj.art-37c044ea54d9441f98ba69bfd8f18f89 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-08T10:45:07Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-37c044ea54d9441f98ba69bfd8f18f892024-01-26T17:19:33ZengMDPI AGJournal of Personalized Medicine2075-44262024-01-011419210.3390/jpm14010092Kidney Biopsy and Immuno-Rheumatological Diseases: A Retrospective and Observational StudyAntonietta Gigante0Rosario Cianci1Annalisa Villa2Chiara Pellicano3Konstantinos Giannakakis4Edoardo Rosato5Francesca Romana Spinelli6Umberto Basile7Cosimo Racco8Elena Maria Di Virgilio9Bruna Cerbelli10Fabrizio Conti11Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, ItalyRheumatology Unit, Department of Clinical Internal, Anaesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Clinical Pathology, Santa Maria Goretti Hospital, AUSL Latina, 04100 Latina, ItalyDepartment of Clinical Pathology, Santa Maria Goretti Hospital, AUSL Latina, 04100 Latina, ItalyDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyRheumatology Unit, Department of Clinical Internal, Anaesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, ItalyRenal involvement is a common occurrence in patients with immuno-rheumatological diseases (IRDs). Several instances of glomerulonephritis (GN) occur in the setting of IRD and complicate the clinical course of an underlying condition. The aim of this study was to observe the spectrum of nephropathies according to age, kidney function, history of IRD at the time of biopsy, and histopathological kidney diagnosis. We evaluated data relating to 699 consecutive kidney native biopsies (female 52.1%) with a median age of 48 years (IQR 34–62) performed in adult patients collected over 15 years. The study population was divided into three groups: patients with kidney histological findings correlated to underlying IRD (Group 1), patients with kidney histological findings not correlated to underlying IRD (Group 2), and patients with kidney histological findings compatible with “de novo” IRD (absent in personal medical history) (Group 3). Kidney involvement related to IRD was found in 25.2% of patients. Group 1 was mostly represented by lupus nephritis (76.6%), with a younger age than Group 3 (<i>p</i> < 0.001) and by a higher percentage of females than other groups (<i>p</i> < 0.001). Group 3 was the most represented by microscopic polyangiitis (50.8%) when compared with the other two groups (<i>p</i> < 0.001). Acute nephritic syndrome (<i>p</i> < 0.001), acute kidney injury (AKI), and abnormal urinalysis (<i>p</i> < 0.001) were more represented in Group 3 than the other groups. In conclusion, IRDs are characterized by different clinical presentations and heterogeneous histological findings. Kidney biopsy remains fundamental to achieving the correct diagnosis and starting targeted therapy.https://www.mdpi.com/2075-4426/14/1/92kidney biopsyautoimmunityimmuno-rheumatological diseasesglomerulonephritisvasculitislupus nephritis |
| spellingShingle | Antonietta Gigante Rosario Cianci Annalisa Villa Chiara Pellicano Konstantinos Giannakakis Edoardo Rosato Francesca Romana Spinelli Umberto Basile Cosimo Racco Elena Maria Di Virgilio Bruna Cerbelli Fabrizio Conti Kidney Biopsy and Immuno-Rheumatological Diseases: A Retrospective and Observational Study Journal of Personalized Medicine kidney biopsy autoimmunity immuno-rheumatological diseases glomerulonephritis vasculitis lupus nephritis |
| title | Kidney Biopsy and Immuno-Rheumatological Diseases: A Retrospective and Observational Study |
| title_full | Kidney Biopsy and Immuno-Rheumatological Diseases: A Retrospective and Observational Study |
| title_fullStr | Kidney Biopsy and Immuno-Rheumatological Diseases: A Retrospective and Observational Study |
| title_full_unstemmed | Kidney Biopsy and Immuno-Rheumatological Diseases: A Retrospective and Observational Study |
| title_short | Kidney Biopsy and Immuno-Rheumatological Diseases: A Retrospective and Observational Study |
| title_sort | kidney biopsy and immuno rheumatological diseases a retrospective and observational study |
| topic | kidney biopsy autoimmunity immuno-rheumatological diseases glomerulonephritis vasculitis lupus nephritis |
| url | https://www.mdpi.com/2075-4426/14/1/92 |
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