Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic Carcinoma
At present, the clinical diagnosis of and treatment methods for hepatic carcinoma still fail to fully meet the needs of patients. The integrated theranostic system, in which functional materials are used to load different active molecules, created a new developmental direction for the combination tr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.750807/full |
| _version_ | 1818559661721255936 |
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| author | Yun Zhou Bixia Lin Kai Li Yufeng Zhao Zhuo Sun Chenchen He Rajiv Kumar Jha |
| author_facet | Yun Zhou Bixia Lin Kai Li Yufeng Zhao Zhuo Sun Chenchen He Rajiv Kumar Jha |
| author_sort | Yun Zhou |
| collection | DOAJ |
| description | At present, the clinical diagnosis of and treatment methods for hepatic carcinoma still fail to fully meet the needs of patients. The integrated theranostic system, in which functional materials are used to load different active molecules, created a new developmental direction for the combination treatment of hepatic carcinoma, realizing the synchronization of diagnosis and treatment. In this study, polydopamine (PDA), which has the functions of self-assembly, encapsulation, photothermal conversion, and photoacoustic interaction, was used as the carrier material. The IR780, a near-infrared fluorescence imaging (NIFI), photoacoustic imaging (PAI), and photothermal therapy (PTT) agent, and paclitaxel (PTX), a broad-spectrum chemotherapy drug, were selected to build the NIF/PA dual-mode imaging and PTT/chemo synergistic theranostic nanoparticles (DIST NPs). The DIST NPs have a 103.4 ± 13.3 nm particle size, a weak negative charge on the surface, good colloidal stability, slow and controlled drug release, and high photothermal conversion ability. The experiments results showed that the DIST NPs have a long circulation in vivo, high bioavailability, high biocompatibility, and low effective dose. DIST NPs showed an excellent NIFI/PAI dual-mode imaging and significant synergistic antitumor effect in hepatic carcinoma models. DIST NPs met the initial design requirements. A set of fast and low-cost preparation methods was established. This study provides an experimental basis for the development of new clinical theranostic methods for hepatic carcinoma. |
| first_indexed | 2024-12-14T00:28:27Z |
| format | Article |
| id | doaj.art-37c08ffdd0284ac4b6f9fd6b78d7a214 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T00:28:27Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-37c08ffdd0284ac4b6f9fd6b78d7a2142022-12-21T23:24:58ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-09-011110.3389/fonc.2021.750807750807Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic CarcinomaYun Zhou0Bixia Lin1Kai Li2Yufeng Zhao3Zhuo Sun4Chenchen He5Rajiv Kumar Jha6College of Clinical Medicine, Xi'an Medical University, Xi’an, ChinaCollege of Pharmacy, Xi'an Medical University, Xi’an, ChinaCollege of Clinical Medicine, Xi'an Medical University, Xi’an, ChinaDepartment of Basic Medical Science, Xi’an Medical University, Xi’an, ChinaDepartment of Basic Medical Science, Xi’an Medical University, Xi’an, ChinaDepartment of Radiation Oncology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaCollege of Clinical Medicine, Xi'an Medical University, Xi’an, ChinaAt present, the clinical diagnosis of and treatment methods for hepatic carcinoma still fail to fully meet the needs of patients. The integrated theranostic system, in which functional materials are used to load different active molecules, created a new developmental direction for the combination treatment of hepatic carcinoma, realizing the synchronization of diagnosis and treatment. In this study, polydopamine (PDA), which has the functions of self-assembly, encapsulation, photothermal conversion, and photoacoustic interaction, was used as the carrier material. The IR780, a near-infrared fluorescence imaging (NIFI), photoacoustic imaging (PAI), and photothermal therapy (PTT) agent, and paclitaxel (PTX), a broad-spectrum chemotherapy drug, were selected to build the NIF/PA dual-mode imaging and PTT/chemo synergistic theranostic nanoparticles (DIST NPs). The DIST NPs have a 103.4 ± 13.3 nm particle size, a weak negative charge on the surface, good colloidal stability, slow and controlled drug release, and high photothermal conversion ability. The experiments results showed that the DIST NPs have a long circulation in vivo, high bioavailability, high biocompatibility, and low effective dose. DIST NPs showed an excellent NIFI/PAI dual-mode imaging and significant synergistic antitumor effect in hepatic carcinoma models. DIST NPs met the initial design requirements. A set of fast and low-cost preparation methods was established. This study provides an experimental basis for the development of new clinical theranostic methods for hepatic carcinoma.https://www.frontiersin.org/articles/10.3389/fonc.2021.750807/fullhepatic carcinomatheranosticnanocarrierdual-mode imagingsynergistic therapy |
| spellingShingle | Yun Zhou Bixia Lin Kai Li Yufeng Zhao Zhuo Sun Chenchen He Rajiv Kumar Jha Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic Carcinoma Frontiers in Oncology hepatic carcinoma theranostic nanocarrier dual-mode imaging synergistic therapy |
| title | Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic Carcinoma |
| title_full | Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic Carcinoma |
| title_fullStr | Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic Carcinoma |
| title_full_unstemmed | Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic Carcinoma |
| title_short | Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic Carcinoma |
| title_sort | preparation of near infrared photoacoustic dual mode imaging and photothermal chemo synergistic theranostic nanoparticles and their imaging and treating of hepatic carcinoma |
| topic | hepatic carcinoma theranostic nanocarrier dual-mode imaging synergistic therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.750807/full |
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