Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung Cancer
Yusuke Yonenaga,1 Tateaki Naito,2 Taro Okayama,1 Midori Kitagawa,1 Noriko Mitsuhashi,1 Takeshi Ishii,1 Hiroshi Fuseya,1 Toshimi Inano,3 Ayumu Morikawa,4 Miwa Sugiyama,4 Keita Mori,5 Akifumi Notsu,5 Takanori Kawabata,5 Akira Ono,2 Hirotsugu Kenmotsu,2 Haruyasu Murakami,2 Akira Tanuma,6 Toshiaki Takah...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-06-01
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| Series: | Journal of Multidisciplinary Healthcare |
| Subjects: | |
| Online Access: | https://www.dovepress.com/impact-of-physical-inactivity-on-the-risk-of-disability-and-hospitaliz-peer-reviewed-fulltext-article-JMDH |
| _version_ | 1818670342782058496 |
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| author | Yonenaga Y Naito T Okayama T Kitagawa M Mitsuhashi N Ishii T Fuseya H Inano T Morikawa A Sugiyama M Mori K Notsu A Kawabata T Ono A Kenmotsu H Murakami H Tanuma A Takahashi T |
| author_facet | Yonenaga Y Naito T Okayama T Kitagawa M Mitsuhashi N Ishii T Fuseya H Inano T Morikawa A Sugiyama M Mori K Notsu A Kawabata T Ono A Kenmotsu H Murakami H Tanuma A Takahashi T |
| author_sort | Yonenaga Y |
| collection | DOAJ |
| description | Yusuke Yonenaga,1 Tateaki Naito,2 Taro Okayama,1 Midori Kitagawa,1 Noriko Mitsuhashi,1 Takeshi Ishii,1 Hiroshi Fuseya,1 Toshimi Inano,3 Ayumu Morikawa,4 Miwa Sugiyama,4 Keita Mori,5 Akifumi Notsu,5 Takanori Kawabata,5 Akira Ono,2 Hirotsugu Kenmotsu,2 Haruyasu Murakami,2 Akira Tanuma,6 Toshiaki Takahashi2 1Division of Rehabilitation Medicine, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 2Division of Thoracic Oncology, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 3Division of Nutrition, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 4Division of Nursing, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 5Clinical Research Center, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 6Department of Rehabilitation Medicine, Juntendo Shizuoka Hospital, Juntendo University School of Medicine, Izunokuni-shi, Shizuoka, JapanCorrespondence: Tateaki NaitoDivision of Thoracic Oncology, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Shizuoka, 411-8777, JapanTel +81-55-989-5222Fax +81-55-989-5783Email t.naito@scchr.jpPurpose: This prospective observational study aimed to explore the influence of physical inactivity during initial chemotherapy on the risk of disability and hospitalization in later life among older patients with advanced non-small-cell lung cancer (NSCLC).Patients and Methods: Patients aged 70 or above who were scheduled to receive first-line chemotherapy for newly diagnosed advanced NSCLC were recruited for the study. An electronic pedometer was used to measure daily steps; based on the change rate (cutoff: − 12.5%) from pretreatment to 12 ± 4 weeks after enrolment, patients were classified as active or inactive. The Barthel Index estimated activities of daily living. We compared disability-free survival time, mean cumulative functions of hospital stays, and medical costs, between the active and inactive groups.Results: Among the 29 patients enrolled, 21 were evaluable. Compared with active patients (n = 11), inactive patients (n = 10) showed shorter disability-free survival (6.4 vs 19.9 months, p < 0.05) and tended to have longer hospital stays (23.7 vs 6.3 days/person) and higher inpatient care cost (¥ 1.6 vs ¥ 0.3 million/person [US$16,000 vs US$3000/person]) during the first year.Conclusion: Physical inactivity during initial chemotherapy may be a risk factor for developing disability and requiring hospitalization in later life for older patients with advanced NSCLC. Our findings may indicate the need for lifestyle interventions with multidisciplinary teams, which include physicians, nurses, and physiotherapists, for older patients with advanced lung cancer during an active cancer treatment. A large-sample-sized study is needed to validate our findings.Keywords: non-small-cell lung cancer, older patients, physical activity, disability-free survival, medical cost, length of hospital stay |
| first_indexed | 2024-12-17T07:06:35Z |
| format | Article |
| id | doaj.art-37c103c0bcf94527b5ae16fad30ed5d1 |
| institution | Directory Open Access Journal |
| issn | 1178-2390 |
| language | English |
| last_indexed | 2024-12-17T07:06:35Z |
| publishDate | 2021-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Multidisciplinary Healthcare |
| spelling | doaj.art-37c103c0bcf94527b5ae16fad30ed5d12022-12-21T21:59:09ZengDove Medical PressJournal of Multidisciplinary Healthcare1178-23902021-06-01Volume 141521153266070Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung CancerYonenaga YNaito TOkayama TKitagawa MMitsuhashi NIshii TFuseya HInano TMorikawa ASugiyama MMori KNotsu AKawabata TOno AKenmotsu HMurakami HTanuma ATakahashi TYusuke Yonenaga,1 Tateaki Naito,2 Taro Okayama,1 Midori Kitagawa,1 Noriko Mitsuhashi,1 Takeshi Ishii,1 Hiroshi Fuseya,1 Toshimi Inano,3 Ayumu Morikawa,4 Miwa Sugiyama,4 Keita Mori,5 Akifumi Notsu,5 Takanori Kawabata,5 Akira Ono,2 Hirotsugu Kenmotsu,2 Haruyasu Murakami,2 Akira Tanuma,6 Toshiaki Takahashi2 1Division of Rehabilitation Medicine, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 2Division of Thoracic Oncology, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 3Division of Nutrition, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 4Division of Nursing, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 5Clinical Research Center, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 6Department of Rehabilitation Medicine, Juntendo Shizuoka Hospital, Juntendo University School of Medicine, Izunokuni-shi, Shizuoka, JapanCorrespondence: Tateaki NaitoDivision of Thoracic Oncology, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Shizuoka, 411-8777, JapanTel +81-55-989-5222Fax +81-55-989-5783Email t.naito@scchr.jpPurpose: This prospective observational study aimed to explore the influence of physical inactivity during initial chemotherapy on the risk of disability and hospitalization in later life among older patients with advanced non-small-cell lung cancer (NSCLC).Patients and Methods: Patients aged 70 or above who were scheduled to receive first-line chemotherapy for newly diagnosed advanced NSCLC were recruited for the study. An electronic pedometer was used to measure daily steps; based on the change rate (cutoff: − 12.5%) from pretreatment to 12 ± 4 weeks after enrolment, patients were classified as active or inactive. The Barthel Index estimated activities of daily living. We compared disability-free survival time, mean cumulative functions of hospital stays, and medical costs, between the active and inactive groups.Results: Among the 29 patients enrolled, 21 were evaluable. Compared with active patients (n = 11), inactive patients (n = 10) showed shorter disability-free survival (6.4 vs 19.9 months, p < 0.05) and tended to have longer hospital stays (23.7 vs 6.3 days/person) and higher inpatient care cost (¥ 1.6 vs ¥ 0.3 million/person [US$16,000 vs US$3000/person]) during the first year.Conclusion: Physical inactivity during initial chemotherapy may be a risk factor for developing disability and requiring hospitalization in later life for older patients with advanced NSCLC. Our findings may indicate the need for lifestyle interventions with multidisciplinary teams, which include physicians, nurses, and physiotherapists, for older patients with advanced lung cancer during an active cancer treatment. A large-sample-sized study is needed to validate our findings.Keywords: non-small-cell lung cancer, older patients, physical activity, disability-free survival, medical cost, length of hospital stayhttps://www.dovepress.com/impact-of-physical-inactivity-on-the-risk-of-disability-and-hospitaliz-peer-reviewed-fulltext-article-JMDHnon-small-cell lung cancerolder patientsphysical activitydisability-free survivalmedical costlength of hospital stay |
| spellingShingle | Yonenaga Y Naito T Okayama T Kitagawa M Mitsuhashi N Ishii T Fuseya H Inano T Morikawa A Sugiyama M Mori K Notsu A Kawabata T Ono A Kenmotsu H Murakami H Tanuma A Takahashi T Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung Cancer Journal of Multidisciplinary Healthcare non-small-cell lung cancer older patients physical activity disability-free survival medical cost length of hospital stay |
| title | Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung Cancer |
| title_full | Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung Cancer |
| title_fullStr | Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung Cancer |
| title_full_unstemmed | Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung Cancer |
| title_short | Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung Cancer |
| title_sort | impact of physical inactivity on the risk of disability and hospitalization in older patients with advanced lung cancer |
| topic | non-small-cell lung cancer older patients physical activity disability-free survival medical cost length of hospital stay |
| url | https://www.dovepress.com/impact-of-physical-inactivity-on-the-risk-of-disability-and-hospitaliz-peer-reviewed-fulltext-article-JMDH |
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