Usefulness of Lung Ultrasound as a Method for Early Diagnosis of Interstitial Lung Disease in Patients with Rheumatoid Arthritis
Pedro Santos-Moreno,1 Maria Fernanda Linares-Contreras,1 Gabriel-Santiago Rodríguez-Vargas,2 Pedro Rodríguez-Linares,2 Abdón Mata-Hurtado,3 Linda Ibatá,4 Susan Martínez,4 Adriana Rojas-Villarraga,1,5 Mario Diaz,1 Esther F Vicente-Rabaneda,6 Maritza Quintero,7 Ingrid Möller7 1Rheumatology Department,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-01-01
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| Series: | Open Access Rheumatology: Research and Reviews |
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| Online Access: | https://www.dovepress.com/usefulness-of-lung-ultrasound-as-a-method-for-early-diagnosis-of-inter-peer-reviewed-fulltext-article-OARRR |
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| author | Santos-Moreno P Linares-Contreras MF Rodríguez-Vargas GS Rodríguez-Linares P Mata-Hurtado A Ibatá L Martínez S Rojas-Villarraga A Diaz M Vicente-Rabaneda EF Quintero M Möller I |
| author_facet | Santos-Moreno P Linares-Contreras MF Rodríguez-Vargas GS Rodríguez-Linares P Mata-Hurtado A Ibatá L Martínez S Rojas-Villarraga A Diaz M Vicente-Rabaneda EF Quintero M Möller I |
| author_sort | Santos-Moreno P |
| collection | DOAJ |
| description | Pedro Santos-Moreno,1 Maria Fernanda Linares-Contreras,1 Gabriel-Santiago Rodríguez-Vargas,2 Pedro Rodríguez-Linares,2 Abdón Mata-Hurtado,3 Linda Ibatá,4 Susan Martínez,4 Adriana Rojas-Villarraga,1,5 Mario Diaz,1 Esther F Vicente-Rabaneda,6 Maritza Quintero,7 Ingrid Möller7 1Rheumatology Department, Biomab IPS, Bogotá, Colombia; 2Research department, Biomab IPS, Bogotá, Colombia; 3Fundación Neumológica Colombiana, Bogotá, Colombia; 4Epidemiology department, Biomab IPS, Bogotá, Colombia; 5Research Institute, Fundación Universitaria de Ciencias de La Salud – FUCS, Bogotá, Colombia; 6Rheumatology, Hospital Universitario La Princesa, Madrid, Spain; 7POAL Rheumatology Institute, Rheumatology, Barcelona, SpainCorrespondence: Pedro Santos-Moreno, Rheumatology department, Biomab IPS, 48th Street #13-86, Bogotá, 110221, Colombia, Tel +57 320 8094232, Email pedrosantosmoreno@hotmail.comPurpose: To determine the value of lung ultrasound (LUS) compared to high-resolution computed tomography (HRCT) in the early diagnosis of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA).Patients and Methods: An observational prospective study was performed. Were included patients with respiratory symptoms or/and, patients with crackles in auscultation during medical consultation. All patients underwent to chest X-rays, LUS, HRCT,and respiratory function tests.Results: A total of 192 patients with RA were included. Mean disease duration was 16.8 ± 11.1 years. 72% were positive for rheumatoid factor or anti-citrullinated antibodies. Of the total number of subjects, 54.7% had respiratory symptoms. The other patients did not have respiratory symptoms, but they did have had crackles on pulmonary auscultation. B lines > 11.5 on the ROC curve predicted ILD (AUC 0.63; CI 95%: 0.55– 0.71; p < 0.003). A DLCO value of < 7.13 significantly predicted the presence of ILD (AUC 0.61; 95% CI: 0.52– 0.70; p < 0.028).Conclusion: The findings of this study suggest that LUS is a valuable tool for the early diagnosis of ILD in patients with RA, and together with DLCO, can adequately predict the presence of ILD in this population. LUS also helps to determine which patients with respiratory symptoms and signs suggestive for ILD are undergo to HRCT.Keywords: rheumatoid arthritis, interstitial lung diseases, respiratory function tests |
| first_indexed | 2024-03-08T13:05:59Z |
| format | Article |
| id | doaj.art-37c226a8955a420ab40a466e2f5963b6 |
| institution | Directory Open Access Journal |
| issn | 1179-156X |
| language | English |
| last_indexed | 2024-03-08T13:05:59Z |
| publishDate | 2024-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Open Access Rheumatology: Research and Reviews |
| spelling | doaj.art-37c226a8955a420ab40a466e2f5963b62024-01-18T18:05:05ZengDove Medical PressOpen Access Rheumatology: Research and Reviews1179-156X2024-01-01Volume 1692089769Usefulness of Lung Ultrasound as a Method for Early Diagnosis of Interstitial Lung Disease in Patients with Rheumatoid ArthritisSantos-Moreno PLinares-Contreras MFRodríguez-Vargas GSRodríguez-Linares PMata-Hurtado AIbatá LMartínez SRojas-Villarraga ADiaz MVicente-Rabaneda EFQuintero MMöller IPedro Santos-Moreno,1 Maria Fernanda Linares-Contreras,1 Gabriel-Santiago Rodríguez-Vargas,2 Pedro Rodríguez-Linares,2 Abdón Mata-Hurtado,3 Linda Ibatá,4 Susan Martínez,4 Adriana Rojas-Villarraga,1,5 Mario Diaz,1 Esther F Vicente-Rabaneda,6 Maritza Quintero,7 Ingrid Möller7 1Rheumatology Department, Biomab IPS, Bogotá, Colombia; 2Research department, Biomab IPS, Bogotá, Colombia; 3Fundación Neumológica Colombiana, Bogotá, Colombia; 4Epidemiology department, Biomab IPS, Bogotá, Colombia; 5Research Institute, Fundación Universitaria de Ciencias de La Salud – FUCS, Bogotá, Colombia; 6Rheumatology, Hospital Universitario La Princesa, Madrid, Spain; 7POAL Rheumatology Institute, Rheumatology, Barcelona, SpainCorrespondence: Pedro Santos-Moreno, Rheumatology department, Biomab IPS, 48th Street #13-86, Bogotá, 110221, Colombia, Tel +57 320 8094232, Email pedrosantosmoreno@hotmail.comPurpose: To determine the value of lung ultrasound (LUS) compared to high-resolution computed tomography (HRCT) in the early diagnosis of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA).Patients and Methods: An observational prospective study was performed. Were included patients with respiratory symptoms or/and, patients with crackles in auscultation during medical consultation. All patients underwent to chest X-rays, LUS, HRCT,and respiratory function tests.Results: A total of 192 patients with RA were included. Mean disease duration was 16.8 ± 11.1 years. 72% were positive for rheumatoid factor or anti-citrullinated antibodies. Of the total number of subjects, 54.7% had respiratory symptoms. The other patients did not have respiratory symptoms, but they did have had crackles on pulmonary auscultation. B lines > 11.5 on the ROC curve predicted ILD (AUC 0.63; CI 95%: 0.55– 0.71; p < 0.003). A DLCO value of < 7.13 significantly predicted the presence of ILD (AUC 0.61; 95% CI: 0.52– 0.70; p < 0.028).Conclusion: The findings of this study suggest that LUS is a valuable tool for the early diagnosis of ILD in patients with RA, and together with DLCO, can adequately predict the presence of ILD in this population. LUS also helps to determine which patients with respiratory symptoms and signs suggestive for ILD are undergo to HRCT.Keywords: rheumatoid arthritis, interstitial lung diseases, respiratory function testshttps://www.dovepress.com/usefulness-of-lung-ultrasound-as-a-method-for-early-diagnosis-of-inter-peer-reviewed-fulltext-article-OARRRrheumatoid arthritisinterstitial lung diseasesrespiratory function tests. |
| spellingShingle | Santos-Moreno P Linares-Contreras MF Rodríguez-Vargas GS Rodríguez-Linares P Mata-Hurtado A Ibatá L Martínez S Rojas-Villarraga A Diaz M Vicente-Rabaneda EF Quintero M Möller I Usefulness of Lung Ultrasound as a Method for Early Diagnosis of Interstitial Lung Disease in Patients with Rheumatoid Arthritis Open Access Rheumatology: Research and Reviews rheumatoid arthritis interstitial lung diseases respiratory function tests. |
| title | Usefulness of Lung Ultrasound as a Method for Early Diagnosis of Interstitial Lung Disease in Patients with Rheumatoid Arthritis |
| title_full | Usefulness of Lung Ultrasound as a Method for Early Diagnosis of Interstitial Lung Disease in Patients with Rheumatoid Arthritis |
| title_fullStr | Usefulness of Lung Ultrasound as a Method for Early Diagnosis of Interstitial Lung Disease in Patients with Rheumatoid Arthritis |
| title_full_unstemmed | Usefulness of Lung Ultrasound as a Method for Early Diagnosis of Interstitial Lung Disease in Patients with Rheumatoid Arthritis |
| title_short | Usefulness of Lung Ultrasound as a Method for Early Diagnosis of Interstitial Lung Disease in Patients with Rheumatoid Arthritis |
| title_sort | usefulness of lung ultrasound as a method for early diagnosis of interstitial lung disease in patients with rheumatoid arthritis |
| topic | rheumatoid arthritis interstitial lung diseases respiratory function tests. |
| url | https://www.dovepress.com/usefulness-of-lung-ultrasound-as-a-method-for-early-diagnosis-of-inter-peer-reviewed-fulltext-article-OARRR |
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