Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol
Aims : The current study was to assess the protective role of resveratrol in cypermethrin-induced reproductive toxicity in male Wistar rats. Materials and Methods : Rats were exposed to cypermethrin (3.83 mg/kg bw) for 14 days. Pre- and post-treatment of resveratrol (20 mg/kg bw for 14 days) was giv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2014;volume=7;issue=2;spage=99;epage=106;aulast=Sharma |
| _version_ | 1819134477800046592 |
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| author | Poonam Sharma Amir Ul Huq Rambir Singh |
| author_facet | Poonam Sharma Amir Ul Huq Rambir Singh |
| author_sort | Poonam Sharma |
| collection | DOAJ |
| description | Aims : The current study was to assess the protective role of resveratrol in cypermethrin-induced reproductive toxicity in male Wistar rats. Materials and Methods : Rats were exposed to cypermethrin (3.83 mg/kg bw) for 14 days. Pre- and post-treatment of resveratrol (20 mg/kg bw for 14 days) was given to cypermethrin exposed rats. At the end of the experiment, rats were sacrificed, testis and epididymis were removed, sperm characteristics, sex hormones, and various biochemical parameters were studied. Results : Cypermethrin exposure resulted in a significant decrease in weight of testis and epididymis, testicular sperm head counts, sperm motility and live sperm counts and increase in sperm abnormalities. Serum testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and total protein (TP) content were decreased and lipid peroxidation (LPO) level was increased on cypermethrin exposure. Pre- and post-treatment of resveratrol increased sperm head counts, sperm motility, live sperm counts, T, FSH, LH, GSH, CAT, SOD, GST, GR, GPx and TP contents and decreased LPO. Treatment with resveratrol alone has improved sperm parameters and testicular antioxidant defence system. Conclusion : The study concluded that resveratrol ameliorated cypermethrin-induced testicular damage by reducing oxidative stress and by enhancing the level of sex hormones. |
| first_indexed | 2024-12-22T10:03:49Z |
| format | Article |
| id | doaj.art-37c29a0361ed460b85fe00afa51ea611 |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-22T10:03:49Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-37c29a0361ed460b85fe00afa51ea6112022-12-21T18:30:01ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662014-01-01729910610.4103/0974-1208.138867Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrolPoonam SharmaAmir Ul HuqRambir SinghAims : The current study was to assess the protective role of resveratrol in cypermethrin-induced reproductive toxicity in male Wistar rats. Materials and Methods : Rats were exposed to cypermethrin (3.83 mg/kg bw) for 14 days. Pre- and post-treatment of resveratrol (20 mg/kg bw for 14 days) was given to cypermethrin exposed rats. At the end of the experiment, rats were sacrificed, testis and epididymis were removed, sperm characteristics, sex hormones, and various biochemical parameters were studied. Results : Cypermethrin exposure resulted in a significant decrease in weight of testis and epididymis, testicular sperm head counts, sperm motility and live sperm counts and increase in sperm abnormalities. Serum testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and total protein (TP) content were decreased and lipid peroxidation (LPO) level was increased on cypermethrin exposure. Pre- and post-treatment of resveratrol increased sperm head counts, sperm motility, live sperm counts, T, FSH, LH, GSH, CAT, SOD, GST, GR, GPx and TP contents and decreased LPO. Treatment with resveratrol alone has improved sperm parameters and testicular antioxidant defence system. Conclusion : The study concluded that resveratrol ameliorated cypermethrin-induced testicular damage by reducing oxidative stress and by enhancing the level of sex hormones.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2014;volume=7;issue=2;spage=99;epage=106;aulast=SharmaCypermethrinoxidative stressresveratrolsex hormonessperm parameters |
| spellingShingle | Poonam Sharma Amir Ul Huq Rambir Singh Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol Journal of Human Reproductive Sciences Cypermethrin oxidative stress resveratrol sex hormones sperm parameters |
| title | Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol |
| title_full | Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol |
| title_fullStr | Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol |
| title_full_unstemmed | Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol |
| title_short | Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol |
| title_sort | cypermethrin induced reproductive toxicity in the rat is prevented by resveratrol |
| topic | Cypermethrin oxidative stress resveratrol sex hormones sperm parameters |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2014;volume=7;issue=2;spage=99;epage=106;aulast=Sharma |
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