Effects of Magnesium Orotate, Benfotiamine and a Combination of Vitamins on Mitochondrial and Cholinergic Function in the TgF344-AD Rat Model of Alzheimer’s Disease

Effects of Magnesium Orotate, Benfotiamine and a Combination of Vitamins on Mitochondrial and Cholinergic Function in the TgF344-AD Rat Model of Alzheimer’s Disease

Glucose hypometabolism, mitochondrial dysfunction, and cholinergic deficits have been reported in early stages of Alzheimer’s disease (AD). Here, we examine these parameters in TgF344-AD rats, an Alzheimer model that carries amyloid precursor protein and presenilin-1 mutations, and of wild type F344...

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Bibliographic Details
Main Authors: Christian Viel, Adrian T. Brandtner, Alexander Weißhaar, Alina Lehto, Marius Fuchs, Jochen Klein
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceuticals
Subjects:
acetylcholine
Alzheimer’s disease
microdialysis
glucose
lactate
mitochondrial respiration
Online Access:https://www.mdpi.com/1424-8247/14/12/1218

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