The first case report: diagnosis and management of necrotizing fusobacterium lung abscess via BALF next-generation sequencing
Abstract Background Fusobacterium necrophorum (F. necrophorum)-induced necrotizing pneumonia is a rare but severe pulmonary infection. Insufficient microbiological detection methods can lead to diagnostic difficulties. Methods We report a case of F. necrophorum lung abscess diagnosed by next-generat...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2024-02-01
|
Series: | BMC Infectious Diseases |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12879-024-09087-5 |
_version_ | 1797275743244255232 |
---|---|
author | Yang Liu Ziye Li Handan Fu Weiliang Ruan Hua Wang Yuhong Ding Miao Zhang |
author_facet | Yang Liu Ziye Li Handan Fu Weiliang Ruan Hua Wang Yuhong Ding Miao Zhang |
author_sort | Yang Liu |
collection | DOAJ |
description | Abstract Background Fusobacterium necrophorum (F. necrophorum)-induced necrotizing pneumonia is a rare but severe pulmonary infection. Insufficient microbiological detection methods can lead to diagnostic difficulties. Methods We report a case of F. necrophorum lung abscess diagnosed by next-generation sequencing (NGS) of bronchoalveolar lavage fluid (BALF). Results BALF-NGS detected F. necrophorum, guiding subsequent targeted antibiotic therapy. With active drainage and metronidazole treatment, the patient’s condition was effectively treated. Conclusion BALF-NGS is a valuable tool for the rapid diagnosis of infections caused by difficult-to-culture bacteria. It played a decisive role in the early identification of F. necrophorum, enabling timely and targeted antibiotic intervention. Early diagnosis and appropriate treatment are crucial for the management of F. necrophorum pneumonia. |
first_indexed | 2024-03-07T15:17:51Z |
format | Article |
id | doaj.art-37c73e4afb194df59332315a81a2d3cc |
institution | Directory Open Access Journal |
issn | 1471-2334 |
language | English |
last_indexed | 2024-03-07T15:17:51Z |
publishDate | 2024-02-01 |
publisher | BMC |
record_format | Article |
series | BMC Infectious Diseases |
spelling | doaj.art-37c73e4afb194df59332315a81a2d3cc2024-03-05T17:48:24ZengBMCBMC Infectious Diseases1471-23342024-02-012411410.1186/s12879-024-09087-5The first case report: diagnosis and management of necrotizing fusobacterium lung abscess via BALF next-generation sequencingYang Liu0Ziye Li1Handan Fu2Weiliang Ruan3Hua Wang4Yuhong Ding5Miao Zhang6Respiratory Department, Shaoxing City Keqiao District Hospital of Traditional Chinese MedicineRespiratory Department, Shaoxing City Keqiao District Hospital of Traditional Chinese MedicineRespiratory Department, Shaoxing City Keqiao District Hospital of Traditional Chinese MedicineRespiratory Department, Shaoxing City Keqiao District Hospital of Traditional Chinese MedicineSpecial Inspection Department, Shaoxing City Keqiao District Hospital of Traditional Chinese MedicineRespiratory Department, Shaoxing City Keqiao District Hospital of Traditional Chinese MedicineRadiology Department, Shaoxing City Keqiao District Hospital of Traditional Chinese MedicineAbstract Background Fusobacterium necrophorum (F. necrophorum)-induced necrotizing pneumonia is a rare but severe pulmonary infection. Insufficient microbiological detection methods can lead to diagnostic difficulties. Methods We report a case of F. necrophorum lung abscess diagnosed by next-generation sequencing (NGS) of bronchoalveolar lavage fluid (BALF). Results BALF-NGS detected F. necrophorum, guiding subsequent targeted antibiotic therapy. With active drainage and metronidazole treatment, the patient’s condition was effectively treated. Conclusion BALF-NGS is a valuable tool for the rapid diagnosis of infections caused by difficult-to-culture bacteria. It played a decisive role in the early identification of F. necrophorum, enabling timely and targeted antibiotic intervention. Early diagnosis and appropriate treatment are crucial for the management of F. necrophorum pneumonia.https://doi.org/10.1186/s12879-024-09087-5Fusobacterium necrophorumLung abscessBronchoalveolar lavage fluidNext-generation sequencingTargeted antibiotic therapy |
spellingShingle | Yang Liu Ziye Li Handan Fu Weiliang Ruan Hua Wang Yuhong Ding Miao Zhang The first case report: diagnosis and management of necrotizing fusobacterium lung abscess via BALF next-generation sequencing BMC Infectious Diseases Fusobacterium necrophorum Lung abscess Bronchoalveolar lavage fluid Next-generation sequencing Targeted antibiotic therapy |
title | The first case report: diagnosis and management of necrotizing fusobacterium lung abscess via BALF next-generation sequencing |
title_full | The first case report: diagnosis and management of necrotizing fusobacterium lung abscess via BALF next-generation sequencing |
title_fullStr | The first case report: diagnosis and management of necrotizing fusobacterium lung abscess via BALF next-generation sequencing |
title_full_unstemmed | The first case report: diagnosis and management of necrotizing fusobacterium lung abscess via BALF next-generation sequencing |
title_short | The first case report: diagnosis and management of necrotizing fusobacterium lung abscess via BALF next-generation sequencing |
title_sort | first case report diagnosis and management of necrotizing fusobacterium lung abscess via balf next generation sequencing |
topic | Fusobacterium necrophorum Lung abscess Bronchoalveolar lavage fluid Next-generation sequencing Targeted antibiotic therapy |
url | https://doi.org/10.1186/s12879-024-09087-5 |
work_keys_str_mv | AT yangliu thefirstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT ziyeli thefirstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT handanfu thefirstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT weiliangruan thefirstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT huawang thefirstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT yuhongding thefirstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT miaozhang thefirstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT yangliu firstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT ziyeli firstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT handanfu firstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT weiliangruan firstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT huawang firstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT yuhongding firstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing AT miaozhang firstcasereportdiagnosisandmanagementofnecrotizingfusobacteriumlungabscessviabalfnextgenerationsequencing |