Multifunctionality of Calebin A in inflammation, chronic diseases and cancer
Chronic diseases including cancer have high case numbers as well as mortality rates. The efficient treatment of chronic diseases is a major ongoing medical challenge worldwide, because of their complexity and many inflammatory pathways such as JNK, p38/MAPK, MEK/ERK, JAK/STAT3, PI3K and NF-κB among...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.962066/full |
| _version_ | 1798033757638230016 |
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| author | Aranka Brockmueller Anna-Lena Mueller Ajaikumar B. Kunnumakkara Bharat B. Aggarwal Mehdi Shakibaei |
| author_facet | Aranka Brockmueller Anna-Lena Mueller Ajaikumar B. Kunnumakkara Bharat B. Aggarwal Mehdi Shakibaei |
| author_sort | Aranka Brockmueller |
| collection | DOAJ |
| description | Chronic diseases including cancer have high case numbers as well as mortality rates. The efficient treatment of chronic diseases is a major ongoing medical challenge worldwide, because of their complexity and many inflammatory pathways such as JNK, p38/MAPK, MEK/ERK, JAK/STAT3, PI3K and NF-κB among others being implicated in their pathogenesis. Together with the versatility of chronic disease classical mono-target therapies are often insufficient. Therefore, the anti-inflammatory as well as anti-cancer capacities of polyphenols are currently investigated to complement and improve the effect of classical anti-inflammatory drugs, chemotherapeutic agents or to overcome drug resistance of cancer cells. Currently, research on Calebin A, a polyphenolic component of turmeric (Curcuma longa), is becoming of growing interest with regard to novel treatment strategies and has already been shown health-promoting as well as anti-tumor properties, including anti-oxidative and anti-inflammatory effects, in diverse cancer cells. Within this review, we describe already known anti-inflammatory activities of Calebin A via modulation of NF-κB and its associated signaling pathways, linked with TNF-α, TNF-β and COX-2 and further summarize Calebin A’s tumor-inhibiting properties that are known up to date such as reduction of cancer cell viability, proliferation as well as metastasis. We also shed light on possible future prospects of Calebin A as an anti-cancer agent. |
| first_indexed | 2024-04-11T20:35:00Z |
| format | Article |
| id | doaj.art-37c7a2395752485da8924353b3c230b6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T20:35:00Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-37c7a2395752485da8924353b3c230b62022-12-22T04:04:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.962066962066Multifunctionality of Calebin A in inflammation, chronic diseases and cancerAranka Brockmueller0Anna-Lena Mueller1Ajaikumar B. Kunnumakkara2Bharat B. Aggarwal3Mehdi Shakibaei4Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Faculty of Medicine, Institute of Anatomy, Ludwig-Maximilians-University Munich, Munich, GermanyMusculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Faculty of Medicine, Institute of Anatomy, Ludwig-Maximilians-University Munich, Munich, GermanyCancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, IndiaInflammation Research Center, San Diego, CA, United StatesMusculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Faculty of Medicine, Institute of Anatomy, Ludwig-Maximilians-University Munich, Munich, GermanyChronic diseases including cancer have high case numbers as well as mortality rates. The efficient treatment of chronic diseases is a major ongoing medical challenge worldwide, because of their complexity and many inflammatory pathways such as JNK, p38/MAPK, MEK/ERK, JAK/STAT3, PI3K and NF-κB among others being implicated in their pathogenesis. Together with the versatility of chronic disease classical mono-target therapies are often insufficient. Therefore, the anti-inflammatory as well as anti-cancer capacities of polyphenols are currently investigated to complement and improve the effect of classical anti-inflammatory drugs, chemotherapeutic agents or to overcome drug resistance of cancer cells. Currently, research on Calebin A, a polyphenolic component of turmeric (Curcuma longa), is becoming of growing interest with regard to novel treatment strategies and has already been shown health-promoting as well as anti-tumor properties, including anti-oxidative and anti-inflammatory effects, in diverse cancer cells. Within this review, we describe already known anti-inflammatory activities of Calebin A via modulation of NF-κB and its associated signaling pathways, linked with TNF-α, TNF-β and COX-2 and further summarize Calebin A’s tumor-inhibiting properties that are known up to date such as reduction of cancer cell viability, proliferation as well as metastasis. We also shed light on possible future prospects of Calebin A as an anti-cancer agent.https://www.frontiersin.org/articles/10.3389/fonc.2022.962066/fullCalebin AturmericNF-κBmitogen-activated protein kinase (MAPK)chronic inflammationsignaling pathways |
| spellingShingle | Aranka Brockmueller Anna-Lena Mueller Ajaikumar B. Kunnumakkara Bharat B. Aggarwal Mehdi Shakibaei Multifunctionality of Calebin A in inflammation, chronic diseases and cancer Frontiers in Oncology Calebin A turmeric NF-κB mitogen-activated protein kinase (MAPK) chronic inflammation signaling pathways |
| title | Multifunctionality of Calebin A in inflammation, chronic diseases and cancer |
| title_full | Multifunctionality of Calebin A in inflammation, chronic diseases and cancer |
| title_fullStr | Multifunctionality of Calebin A in inflammation, chronic diseases and cancer |
| title_full_unstemmed | Multifunctionality of Calebin A in inflammation, chronic diseases and cancer |
| title_short | Multifunctionality of Calebin A in inflammation, chronic diseases and cancer |
| title_sort | multifunctionality of calebin a in inflammation chronic diseases and cancer |
| topic | Calebin A turmeric NF-κB mitogen-activated protein kinase (MAPK) chronic inflammation signaling pathways |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.962066/full |
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