Dynamics of biochemical and immunological blood markers in patients with pseudoarthrosis of the femoral neck after total hip arthroplasty
The importance of biomarkers to predict recovery following total hip arthroplasty (THA) is still unclear to clinicians. To assess the preoperative biomarkers of patients with pseudoarthrosis of the femoral neck and their dynamics in the early postoperative period after THA, 50 patients aged 33 to 82...
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| Format: | Article |
| Language: | English |
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Oles Honchar Dnipro National University
2017-08-01
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| Series: | Regulatory Mechanisms in Biosystems |
| Subjects: | |
| Online Access: | https://medicine.dp.ua/index.php/med/article/view/360 |
| _version_ | 1811249240672829440 |
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| author | S. E. Bondarenko M. Akonjom V. A. Filipenko D. V. Morozenko A. Badnaoui K. V. Gliebova |
| author_facet | S. E. Bondarenko M. Akonjom V. A. Filipenko D. V. Morozenko A. Badnaoui K. V. Gliebova |
| author_sort | S. E. Bondarenko |
| collection | DOAJ |
| description | The importance of biomarkers to predict recovery following total hip arthroplasty (THA) is still unclear to clinicians. To assess the preoperative biomarkers of patients with pseudoarthrosis of the femoral neck and their dynamics in the early postoperative period after THA, 50 patients aged 33 to 82 years old, 18 males and 32 females diagnosed with pseudoarthrosis of the femoral neck after failed internal fixation and failed conservative management were studied. The control group consisted of 30 healthy people aged 27 to 50 years, 13 males, 17 females. Patients’ blood was examined for biochemical markers upon admission, and then on the 7th and 14th days after surgery. Their blood serum content of total protein, albumin, glycoproteins, sialic acids, chondroitin sulfates, haptoglobin, glucose, cholesterol, triglycerides, ALT, AST, alkaline phosphatase, GGT, acid phosphatase, thymol index; interleukins (IL-1, IL-4 and IL-6.) and C-reactive protein was measured. The content of glycoproteins in the blood exceeded the norm by 2.3 times, chondroitin sulfate by 4.7 times, sialic acids by 1.5 times, haptoglobin by 55.8%, fibrinogen by 19.1%, globulin by 19,6%, alkaline phosphatase activity by 72.3%, IL-1 by 94.7 and IL-6 by 3 times, C-reactive protein by 2.6 times. After THA there was a gradual decrease in blood biochemical and immunological markers. The most informative laboratory markers were glycoproteins, chondroitin sulfates, sialic acids, haptoglobin, activity of alkaline phosphatase, IL-1, IL-6 and IL-4, and C-reactive protein. Subsequent research is required to validate these dynamics. |
| first_indexed | 2024-04-12T15:43:05Z |
| format | Article |
| id | doaj.art-37c9a5f27ca24b8a94d9f707f3130c2b |
| institution | Directory Open Access Journal |
| issn | 2519-8521 |
| language | English |
| last_indexed | 2024-04-12T15:43:05Z |
| publishDate | 2017-08-01 |
| publisher | Oles Honchar Dnipro National University |
| record_format | Article |
| series | Regulatory Mechanisms in Biosystems |
| spelling | doaj.art-37c9a5f27ca24b8a94d9f707f3130c2b2022-12-22T03:26:44ZengOles Honchar Dnipro National UniversityRegulatory Mechanisms in Biosystems2519-85212017-08-018342342610.15421/021765322Dynamics of biochemical and immunological blood markers in patients with pseudoarthrosis of the femoral neck after total hip arthroplastyS. E. Bondarenko0M. Akonjom1V. A. Filipenko2D. V. Morozenko3A. Badnaoui4K. V. Gliebova5Sytenko Institute of Spine and Joint Pathology National Academy of Medical Science of UkraineSytenko Institute of Spine and Joint Pathology National Academy of Medical Science of UkraineSytenko Institute of Spine and Joint Pathology National Academy of Medical Science of UkraineSytenko Institute of Spine and Joint Pathology National Academy of Medical Science of UkraineSytenko Institute of Spine and Joint Pathology National Academy of Medical Science of UkraineNational University of PharmacyThe importance of biomarkers to predict recovery following total hip arthroplasty (THA) is still unclear to clinicians. To assess the preoperative biomarkers of patients with pseudoarthrosis of the femoral neck and their dynamics in the early postoperative period after THA, 50 patients aged 33 to 82 years old, 18 males and 32 females diagnosed with pseudoarthrosis of the femoral neck after failed internal fixation and failed conservative management were studied. The control group consisted of 30 healthy people aged 27 to 50 years, 13 males, 17 females. Patients’ blood was examined for biochemical markers upon admission, and then on the 7th and 14th days after surgery. Their blood serum content of total protein, albumin, glycoproteins, sialic acids, chondroitin sulfates, haptoglobin, glucose, cholesterol, triglycerides, ALT, AST, alkaline phosphatase, GGT, acid phosphatase, thymol index; interleukins (IL-1, IL-4 and IL-6.) and C-reactive protein was measured. The content of glycoproteins in the blood exceeded the norm by 2.3 times, chondroitin sulfate by 4.7 times, sialic acids by 1.5 times, haptoglobin by 55.8%, fibrinogen by 19.1%, globulin by 19,6%, alkaline phosphatase activity by 72.3%, IL-1 by 94.7 and IL-6 by 3 times, C-reactive protein by 2.6 times. After THA there was a gradual decrease in blood biochemical and immunological markers. The most informative laboratory markers were glycoproteins, chondroitin sulfates, sialic acids, haptoglobin, activity of alkaline phosphatase, IL-1, IL-6 and IL-4, and C-reactive protein. Subsequent research is required to validate these dynamics.https://medicine.dp.ua/index.php/med/article/view/360biomarkersinterleukinsglycoproteinssialic acidstotal hip replacement |
| spellingShingle | S. E. Bondarenko M. Akonjom V. A. Filipenko D. V. Morozenko A. Badnaoui K. V. Gliebova Dynamics of biochemical and immunological blood markers in patients with pseudoarthrosis of the femoral neck after total hip arthroplasty Regulatory Mechanisms in Biosystems biomarkers interleukins glycoproteins sialic acids total hip replacement |
| title | Dynamics of biochemical and immunological blood markers in patients with pseudoarthrosis of the femoral neck after total hip arthroplasty |
| title_full | Dynamics of biochemical and immunological blood markers in patients with pseudoarthrosis of the femoral neck after total hip arthroplasty |
| title_fullStr | Dynamics of biochemical and immunological blood markers in patients with pseudoarthrosis of the femoral neck after total hip arthroplasty |
| title_full_unstemmed | Dynamics of biochemical and immunological blood markers in patients with pseudoarthrosis of the femoral neck after total hip arthroplasty |
| title_short | Dynamics of biochemical and immunological blood markers in patients with pseudoarthrosis of the femoral neck after total hip arthroplasty |
| title_sort | dynamics of biochemical and immunological blood markers in patients with pseudoarthrosis of the femoral neck after total hip arthroplasty |
| topic | biomarkers interleukins glycoproteins sialic acids total hip replacement |
| url | https://medicine.dp.ua/index.php/med/article/view/360 |
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