Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease
Background: Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disease. We investigated whether serum inflammatory markers, C-reactive protein (CRP), leptin, and nutritional status (assessed by measurement of serum levels of prealbumin and anthropometry) correlated with COPD sev...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Lung India |
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| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2019;volume=36;issue=5;spage=393;epage=398;aulast=Arora |
| _version_ | 1828759359953305600 |
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| author | Sneh Arora Karan Madan Anant Mohan Mani Kalaivani Randeep Guleria |
| author_facet | Sneh Arora Karan Madan Anant Mohan Mani Kalaivani Randeep Guleria |
| author_sort | Sneh Arora |
| collection | DOAJ |
| description | Background: Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disease. We investigated whether serum inflammatory markers, C-reactive protein (CRP), leptin, and nutritional status (assessed by measurement of serum levels of prealbumin and anthropometry) correlated with COPD severity. Materials and Methods: One-hundred and two COPD patients (mean age 56.94 ± 10.95 years) were recruited and classified into severity categories based on the GOLD guidelines. Serum concentrations of CRP, prealbumin, and leptin were measured. Anthropometry included body mass index (BMI), mid-upper arm circumference (MUAC), and sum of four skinfold thicknesses (triceps, biceps, suprailiac, and subscapular). Results: Twenty-one patients had moderate, 44 had severe, and 37 had very severe COPD. Levels of CRP (mg/dl) (mean ± standard error [SE]) in moderate, severe, and very severe COPD were 0.60 ± 0.096, 2.16 ± 0.39, and 4.15 ± 0.463, respectively. Levels of prealbumin (mg/dl) (mean ± SE) in moderate, severe, and very severe COPD were 15.7 3 ± 0.92, 10.95 ± 0.85, and 11.15 ± 0.79 mg/dl, respectively. Levels of leptin (ng/ml) (mean ± SE) in moderate, severe, and very severe COPD were 13.81 ± 3.88, 8.45 ± 2.25, and 4.40 ± 1.06, respectively. BMI values in the three groups were 23.44 ± 1.16 kg/m2, 20.33 ± 0.62 kg/m2, and 18.86 ± 0.52 kg/m2, respectively. Sum of four skinfold thickness and MUAC was significantly reduced in very severe group as compared to moderate and severe group. Very severe COPD patients had a significantly lower leptin, BMI, and 6-min walk test. Serum CRP was significantly higher in very severe COPD. Conclusion: Patients with increasing severity of COPD had a significantly greater serum inflammatory marker level and poorer nutritional status. |
| first_indexed | 2024-12-11T00:56:06Z |
| format | Article |
| id | doaj.art-37cb39ae0b514640940e4098adac5f4b |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-12-11T00:56:06Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-37cb39ae0b514640940e4098adac5f4b2022-12-22T01:26:28ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2019-01-0136539339810.4103/lungindia.lungindia_494_18Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary diseaseSneh AroraKaran MadanAnant MohanMani KalaivaniRandeep GuleriaBackground: Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disease. We investigated whether serum inflammatory markers, C-reactive protein (CRP), leptin, and nutritional status (assessed by measurement of serum levels of prealbumin and anthropometry) correlated with COPD severity. Materials and Methods: One-hundred and two COPD patients (mean age 56.94 ± 10.95 years) were recruited and classified into severity categories based on the GOLD guidelines. Serum concentrations of CRP, prealbumin, and leptin were measured. Anthropometry included body mass index (BMI), mid-upper arm circumference (MUAC), and sum of four skinfold thicknesses (triceps, biceps, suprailiac, and subscapular). Results: Twenty-one patients had moderate, 44 had severe, and 37 had very severe COPD. Levels of CRP (mg/dl) (mean ± standard error [SE]) in moderate, severe, and very severe COPD were 0.60 ± 0.096, 2.16 ± 0.39, and 4.15 ± 0.463, respectively. Levels of prealbumin (mg/dl) (mean ± SE) in moderate, severe, and very severe COPD were 15.7 3 ± 0.92, 10.95 ± 0.85, and 11.15 ± 0.79 mg/dl, respectively. Levels of leptin (ng/ml) (mean ± SE) in moderate, severe, and very severe COPD were 13.81 ± 3.88, 8.45 ± 2.25, and 4.40 ± 1.06, respectively. BMI values in the three groups were 23.44 ± 1.16 kg/m2, 20.33 ± 0.62 kg/m2, and 18.86 ± 0.52 kg/m2, respectively. Sum of four skinfold thickness and MUAC was significantly reduced in very severe group as compared to moderate and severe group. Very severe COPD patients had a significantly lower leptin, BMI, and 6-min walk test. Serum CRP was significantly higher in very severe COPD. Conclusion: Patients with increasing severity of COPD had a significantly greater serum inflammatory marker level and poorer nutritional status.http://www.lungindia.com/article.asp?issn=0970-2113;year=2019;volume=36;issue=5;spage=393;epage=398;aulast=AroraChronic obstructive pulmonary diseaseC-reactive proteininflammationleptinnutritionprealbumin |
| spellingShingle | Sneh Arora Karan Madan Anant Mohan Mani Kalaivani Randeep Guleria Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease Lung India Chronic obstructive pulmonary disease C-reactive protein inflammation leptin nutrition prealbumin |
| title | Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease |
| title_full | Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease |
| title_fullStr | Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease |
| title_full_unstemmed | Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease |
| title_short | Serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease |
| title_sort | serum inflammatory markers and nutritional status in patients with stable chronic obstructive pulmonary disease |
| topic | Chronic obstructive pulmonary disease C-reactive protein inflammation leptin nutrition prealbumin |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2019;volume=36;issue=5;spage=393;epage=398;aulast=Arora |
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