The Effects of Carbon Tetrachloride Administration on Liver and Renal Function
Carbon tetrachloride (CCl4) that induces liver damage is widely used in hepatoprotector experiments. Carbon tetrachloride at a single dose 0,1; 1,0; and 10 ml/kg body weight was administrated intraperitoneally in male rats to investigate liver and renal damage. Liver damage was monitored by increase...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Indonesia
2010-10-01
|
| Series: | Makara Journal of Health Research |
| Subjects: | |
| Online Access: | http://journal.ui.ac.id/index.php/health/article/view/217 |
| _version_ | 1797766159191244800 |
|---|---|
| author | Ruqiah Ganda Putri Panjaitan Ekowati Handharyani Chairul Chairul Masriani Masriani Zulfa Zakiah Wasmen Manalu |
| author_facet | Ruqiah Ganda Putri Panjaitan Ekowati Handharyani Chairul Chairul Masriani Masriani Zulfa Zakiah Wasmen Manalu |
| author_sort | Ruqiah Ganda Putri Panjaitan |
| collection | DOAJ |
| description | Carbon tetrachloride (CCl4) that induces liver damage is widely used in hepatoprotector experiments. Carbon tetrachloride at a single dose 0,1; 1,0; and 10 ml/kg body weight was administrated intraperitoneally in male rats to investigate liver and renal damage. Liver damage was monitored by increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin, and serum total protein. Increased serum creatinine is an indicator of renal problem. Futhermore, liver and renal tissues were subjected to histopathological studies. Compared with control, injection of 0,1 and 1,0 ml CCl4/kg body weight increased ALT and decreased AST, and at dose 10 ml/kg body weight both ALT and AST decreased to a greater extent (p<0.05). Alkaline phosphatase, total bilirubin, and total protein were not different in all treatments (p>0.05). Carbon tetrachloride at dose 0,1 and 1,0 ml/kg body weight increased creatinine. However, injection of 10 ml CCl4/kg body weight decreased creatinine (p<0.05). Histopathological studies confirmed the presence of steatosis in hepatic cells at single dose of 1,0 and 10 ml CCl4/kg body weight, with no significant effect in glomerulus. Administration of single dose of CCl4 can induce liver and renal damage that dependent on CCl4 received. |
| first_indexed | 2024-03-12T20:20:15Z |
| format | Article |
| id | doaj.art-37ce2c0250454bec9f436da9a95a2385 |
| institution | Directory Open Access Journal |
| issn | 2356-3664 2356-3656 |
| language | English |
| last_indexed | 2024-03-12T20:20:15Z |
| publishDate | 2010-10-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Makara Journal of Health Research |
| spelling | doaj.art-37ce2c0250454bec9f436da9a95a23852023-08-02T00:59:06ZengUniversitas IndonesiaMakara Journal of Health Research2356-36642356-36562010-10-01111111610.7454/msk.v11i1.217212The Effects of Carbon Tetrachloride Administration on Liver and Renal FunctionRuqiah Ganda Putri Panjaitan0Ekowati Handharyani1Chairul Chairul2Masriani Masriani3Zulfa Zakiah4Wasmen Manalu5Department of Biology, Faculty of Teacher Training and Education, Tanjungpura University, PontianakDepartment of Veterinary Clinic and Pathology, Faculty of Veterinary Medicine, Institut Pertanian Bogor, Bogor 16680Botanics Division, Center for Research, Indonesian Institute of Sciences, CibinongDepartment of Chemistry, Faculty of Teacher Training and Education, Tanjungpura University, PontianakDepartment of Biology, Faculty of Mathematics and Natural Sciences, Tanjungpura University, PontianakDepartment of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, Institut Pertanian Bogor, Bogor 16680Carbon tetrachloride (CCl4) that induces liver damage is widely used in hepatoprotector experiments. Carbon tetrachloride at a single dose 0,1; 1,0; and 10 ml/kg body weight was administrated intraperitoneally in male rats to investigate liver and renal damage. Liver damage was monitored by increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin, and serum total protein. Increased serum creatinine is an indicator of renal problem. Futhermore, liver and renal tissues were subjected to histopathological studies. Compared with control, injection of 0,1 and 1,0 ml CCl4/kg body weight increased ALT and decreased AST, and at dose 10 ml/kg body weight both ALT and AST decreased to a greater extent (p<0.05). Alkaline phosphatase, total bilirubin, and total protein were not different in all treatments (p>0.05). Carbon tetrachloride at dose 0,1 and 1,0 ml/kg body weight increased creatinine. However, injection of 10 ml CCl4/kg body weight decreased creatinine (p<0.05). Histopathological studies confirmed the presence of steatosis in hepatic cells at single dose of 1,0 and 10 ml CCl4/kg body weight, with no significant effect in glomerulus. Administration of single dose of CCl4 can induce liver and renal damage that dependent on CCl4 received.http://journal.ui.ac.id/index.php/health/article/view/217Carbon tetrachloridehepatotoxicityhistopathology of liver and renal |
| spellingShingle | Ruqiah Ganda Putri Panjaitan Ekowati Handharyani Chairul Chairul Masriani Masriani Zulfa Zakiah Wasmen Manalu The Effects of Carbon Tetrachloride Administration on Liver and Renal Function Makara Journal of Health Research Carbon tetrachloride hepatotoxicity histopathology of liver and renal |
| title | The Effects of Carbon Tetrachloride Administration on Liver and Renal Function |
| title_full | The Effects of Carbon Tetrachloride Administration on Liver and Renal Function |
| title_fullStr | The Effects of Carbon Tetrachloride Administration on Liver and Renal Function |
| title_full_unstemmed | The Effects of Carbon Tetrachloride Administration on Liver and Renal Function |
| title_short | The Effects of Carbon Tetrachloride Administration on Liver and Renal Function |
| title_sort | effects of carbon tetrachloride administration on liver and renal function |
| topic | Carbon tetrachloride hepatotoxicity histopathology of liver and renal |
| url | http://journal.ui.ac.id/index.php/health/article/view/217 |
| work_keys_str_mv | AT ruqiahgandaputripanjaitan theeffectsofcarbontetrachlorideadministrationonliverandrenalfunction AT ekowatihandharyani theeffectsofcarbontetrachlorideadministrationonliverandrenalfunction AT chairulchairul theeffectsofcarbontetrachlorideadministrationonliverandrenalfunction AT masrianimasriani theeffectsofcarbontetrachlorideadministrationonliverandrenalfunction AT zulfazakiah theeffectsofcarbontetrachlorideadministrationonliverandrenalfunction AT wasmenmanalu theeffectsofcarbontetrachlorideadministrationonliverandrenalfunction AT ruqiahgandaputripanjaitan effectsofcarbontetrachlorideadministrationonliverandrenalfunction AT ekowatihandharyani effectsofcarbontetrachlorideadministrationonliverandrenalfunction AT chairulchairul effectsofcarbontetrachlorideadministrationonliverandrenalfunction AT masrianimasriani effectsofcarbontetrachlorideadministrationonliverandrenalfunction AT zulfazakiah effectsofcarbontetrachlorideadministrationonliverandrenalfunction AT wasmenmanalu effectsofcarbontetrachlorideadministrationonliverandrenalfunction |