Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling
Summary: Designing new functional motifs with unique properties is an important objective in the realm of synthetic biology. We uncover emergent properties of positive feedback loops (PFLs) under dual input signaling using pseudo potential energy-based high-throughput bifurcation analysis. We show t...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422300456X |
| _version_ | 1797860338499059712 |
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| author | Soutrick Das Debashis Barik |
| author_facet | Soutrick Das Debashis Barik |
| author_sort | Soutrick Das |
| collection | DOAJ |
| description | Summary: Designing new functional motifs with unique properties is an important objective in the realm of synthetic biology. We uncover emergent properties of positive feedback loops (PFLs) under dual input signaling using pseudo potential energy-based high-throughput bifurcation analysis. We show that under dual signaling a single PFL generates a variety of noncanonical bistable switches, with one or more bistable regions, due to fusion of multiple canonical bistable switches. Regulatory signs of the dual signaling must be coherent for mutual inhibition loop and incoherent for mutual activation loop of the PFL. Occurrence probabilities show that some of the noncanonical switches, such as isola and mushroom, are highly recurrent under random parameterization. Phase diagrams of the noncanonical switches reveal that feedback strengths of the PFL control the transition from one switch to another. Our calculations decipher the design principles of noncanonical bistable switches that originate from synthetically feasible simple PFL motifs under dual signaling. |
| first_indexed | 2024-04-09T21:45:22Z |
| format | Article |
| id | doaj.art-37cfae339a614ef8b348ffe1eb35f7bd |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-09T21:45:22Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-37cfae339a614ef8b348ffe1eb35f7bd2023-03-25T05:14:13ZengElsevieriScience2589-00422023-04-01264106379Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signalingSoutrick Das0Debashis Barik1School of Chemistry, University of Hyderabad, Central University P.O., Hyderabad, Telangana 500046, IndiaSchool of Chemistry, University of Hyderabad, Central University P.O., Hyderabad, Telangana 500046, India; Corresponding authorSummary: Designing new functional motifs with unique properties is an important objective in the realm of synthetic biology. We uncover emergent properties of positive feedback loops (PFLs) under dual input signaling using pseudo potential energy-based high-throughput bifurcation analysis. We show that under dual signaling a single PFL generates a variety of noncanonical bistable switches, with one or more bistable regions, due to fusion of multiple canonical bistable switches. Regulatory signs of the dual signaling must be coherent for mutual inhibition loop and incoherent for mutual activation loop of the PFL. Occurrence probabilities show that some of the noncanonical switches, such as isola and mushroom, are highly recurrent under random parameterization. Phase diagrams of the noncanonical switches reveal that feedback strengths of the PFL control the transition from one switch to another. Our calculations decipher the design principles of noncanonical bistable switches that originate from synthetically feasible simple PFL motifs under dual signaling.http://www.sciencedirect.com/science/article/pii/S258900422300456XMathematical biosciencesSystems biologyData processing in systems biologySynthetic biology |
| spellingShingle | Soutrick Das Debashis Barik Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling iScience Mathematical biosciences Systems biology Data processing in systems biology Synthetic biology |
| title | Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling |
| title_full | Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling |
| title_fullStr | Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling |
| title_full_unstemmed | Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling |
| title_short | Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling |
| title_sort | origin heterogeneity and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling |
| topic | Mathematical biosciences Systems biology Data processing in systems biology Synthetic biology |
| url | http://www.sciencedirect.com/science/article/pii/S258900422300456X |
| work_keys_str_mv | AT soutrickdas originheterogeneityandinterconversionofnoncanonicalbistableswitchesfromthepositivefeedbackloopsunderdualsignaling AT debashisbarik originheterogeneityandinterconversionofnoncanonicalbistableswitchesfromthepositivefeedbackloopsunderdualsignaling |