Loss of GABA co-transmission from cholinergic neurons impairs behaviors related to hippocampal, striatal, and medial prefrontal cortex functions

Loss of GABA co-transmission from cholinergic neurons impairs behaviors related to hippocampal, striatal, and medial prefrontal cortex functions

Introduction: Altered signaling or function of acetylcholine (ACh) has been reported in various neurological diseases, including Alzheimer’s disease, Tourette syndrome, epilepsy among others. Many neurons that release ACh also co-transmit the neurotransmitter gamma-aminobutyrate (GABA) at synapses i...

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Bibliographic Details
Main Authors: R. Oliver Goral, Kathryn M. Harper, Briana J. Bernstein, Sydney A. Fry, Patricia W. Lamb, Sheryl S. Moy, Jesse D. Cushman, Jerrel L. Yakel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
acetylcholine
GABA
co-transmission
animal behavior
transgenic mice
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1067409/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1067409/full

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