Platelet-derived microRNA-223 attenuates TNF-α induced monocytes adhesion to arterial endothelium by targeting ICAM-1 in Kawasaki disease

Platelet-derived microRNA-223 attenuates TNF-α induced monocytes adhesion to arterial endothelium by targeting ICAM-1 in Kawasaki disease

BackgroundKawasaki disease (KD) is an acute vasculitis that may result in permanent coronary artery damage with unknown etiology. Endothelial cell (EC) dysfunction and platelet hyperactivity are the hallmarks of KD. Platelets are involved in the development of endothelial dysfunction. MiR-223 transf...

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Bibliographic Details
Main Authors: Manli Guo, Shunyang Fan, Qian Chen, Cuiping Jia, Miaoyun Qiu, Yun Bu, Wai Ho Tang, Yuan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
Kawasaki disease
endothelial cells
miR-223
platelets
ICAM-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.922868/full

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