Porokeratosis: Two Faces, One Family
Porokeratosis is a disorder of keratinisation whose pathogenesis is yet unclear. It has been postulated that it results from the proliferation of an abnormal clone of keratinocytes, triggered by several factors, such as immunosuppression or prolonged ultraviolet exposure. Various clinical forms are...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2009-10-01
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| Series: | Case Reports in Dermatology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/241414 |
| _version_ | 1819072535829938176 |
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| author | S. Lembo L. Panariello L. Nugnes C. Lembo F. Alaya |
| author_facet | S. Lembo L. Panariello L. Nugnes C. Lembo F. Alaya |
| author_sort | S. Lembo |
| collection | DOAJ |
| description | Porokeratosis is a disorder of keratinisation whose pathogenesis is yet unclear. It has been postulated that it results from the proliferation of an abnormal clone of keratinocytes, triggered by several factors, such as immunosuppression or prolonged ultraviolet exposure. Various clinical forms are recognized whose common denominator is a keratotic ring surrounding a central zone of atrophy. The histological hallmark is the cornoid lamella, a thin column of hyperproliferative abnormal keratinocytes. We describe two cases of porokeratosis. A 67-year-old woman with an erythematous purplish round plaque surrounded by a keratotic border that had appeared 6 years previously on the left sural region was diagnosed as ‘giant’ porokeratosis. A 49-year-old man presented with small papules coalescent in an erythematous oval plaque on the lateral side of the left foot consistent with linear porokeratosis. |
| first_indexed | 2024-12-21T17:39:17Z |
| format | Article |
| id | doaj.art-37d3833b55b947cfb77da2db1f3e2b76 |
| institution | Directory Open Access Journal |
| issn | 1662-6567 |
| language | English |
| last_indexed | 2024-12-21T17:39:17Z |
| publishDate | 2009-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Dermatology |
| spelling | doaj.art-37d3833b55b947cfb77da2db1f3e2b762022-12-21T18:55:40ZengKarger PublishersCase Reports in Dermatology1662-65672009-10-0111525510.1159/000241414241414Porokeratosis: Two Faces, One FamilyS. LemboL. PanarielloL. NugnesC. LemboF. AlayaPorokeratosis is a disorder of keratinisation whose pathogenesis is yet unclear. It has been postulated that it results from the proliferation of an abnormal clone of keratinocytes, triggered by several factors, such as immunosuppression or prolonged ultraviolet exposure. Various clinical forms are recognized whose common denominator is a keratotic ring surrounding a central zone of atrophy. The histological hallmark is the cornoid lamella, a thin column of hyperproliferative abnormal keratinocytes. We describe two cases of porokeratosis. A 67-year-old woman with an erythematous purplish round plaque surrounded by a keratotic border that had appeared 6 years previously on the left sural region was diagnosed as ‘giant’ porokeratosis. A 49-year-old man presented with small papules coalescent in an erythematous oval plaque on the lateral side of the left foot consistent with linear porokeratosis.http://www.karger.com/Article/FullText/241414Giant porokeratosisLinear porokeratosisCornoid lamellaAbnormal clone of keratinocytes |
| spellingShingle | S. Lembo L. Panariello L. Nugnes C. Lembo F. Alaya Porokeratosis: Two Faces, One Family Case Reports in Dermatology Giant porokeratosis Linear porokeratosis Cornoid lamella Abnormal clone of keratinocytes |
| title | Porokeratosis: Two Faces, One Family |
| title_full | Porokeratosis: Two Faces, One Family |
| title_fullStr | Porokeratosis: Two Faces, One Family |
| title_full_unstemmed | Porokeratosis: Two Faces, One Family |
| title_short | Porokeratosis: Two Faces, One Family |
| title_sort | porokeratosis two faces one family |
| topic | Giant porokeratosis Linear porokeratosis Cornoid lamella Abnormal clone of keratinocytes |
| url | http://www.karger.com/Article/FullText/241414 |
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