Postoperative Neutrophil to Lymphocyte Ratio as an Overall Mortality Midterm Prognostic Factor following OPCAB Procedures
Background: Off-pump coronary artery bypass grafting (OPCAB) is believed to limit inflammatory reaction. Neutrophil to lymphocyte ratio (NLR) is one of the more common and easily accessible markers of inflammatory response. The aim of the study was to compare postoperative results of NLR with mid-te...
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MDPI AG
2021-09-01
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| Series: | Clinics and Practice |
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| Online Access: | https://www.mdpi.com/2039-7283/11/3/74 |
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| author | Tomasz Urbanowicz Michał Michalak Aleksandra Gąsecka Bartłomiej Perek Michał Rodzki Michał Bociański Ewa Straburzyńska-Migaj Marek Jemielity |
| author_facet | Tomasz Urbanowicz Michał Michalak Aleksandra Gąsecka Bartłomiej Perek Michał Rodzki Michał Bociański Ewa Straburzyńska-Migaj Marek Jemielity |
| author_sort | Tomasz Urbanowicz |
| collection | DOAJ |
| description | Background: Off-pump coronary artery bypass grafting (OPCAB) is believed to limit inflammatory reaction. Neutrophil to lymphocyte ratio (NLR) is one of the more common and easily accessible markers of inflammatory response. The aim of the study was to compare postoperative results of NLR with mid-term OPCAB results. Methods: In total, 224 patients (198 (88%) men and 26 (12%) women) with mean age 65 +/− 9 years who underwent OPCAB though median full sternotomy in our department in 2018 enrolled into the study. We scrupulously collected the postoperative mid-term results, including survival rate, clinical status and risk for major adverse events, and compared them with perioperative laboratory results. Results: A three-year follow-up was completed by 198 individuals (90% survival rate) with 12 (5%) showing major adverse cardiovascular (MACE) events risk. In the multivariable analysis, the laboratory parameters noticed on the 1st postoperative day were statistically significantly predictive of survival, including neutrophils (HR 1.59, 1.33–1.89 95%CI, <i>p</i> < 0.0001), platelets (HR 1.01, 1.01–1.01 95%CI, <i>p</i> = 0.0065), NLR (HR 1.47, 1.3–1.65 95%CI, <i>p</i> < 0.0001) and postoperative ejection fraction (HR 0.9, 0.87–0.95 95%CI, <i>p</i> < 0.0001). Conclusions: Postoperative NLR above 4.6, as an inflammatory reaction marker, is related to mid-term mortality in OPCAB patients. |
| first_indexed | 2024-03-10T07:47:14Z |
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| language | English |
| last_indexed | 2024-03-10T07:47:14Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
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| series | Clinics and Practice |
| spelling | doaj.art-37d69667c3e94769838df31564af54142023-11-22T12:32:25ZengMDPI AGClinics and Practice2039-72832021-09-0111358759710.3390/clinpract11030074Postoperative Neutrophil to Lymphocyte Ratio as an Overall Mortality Midterm Prognostic Factor following OPCAB ProceduresTomasz Urbanowicz0Michał Michalak1Aleksandra Gąsecka2Bartłomiej Perek3Michał Rodzki4Michał Bociański5Ewa Straburzyńska-Migaj6Marek Jemielity7Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Poznan, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, 60-806 Poznan, PolandDepartment of Cardiology Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Poznan, PolandDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Poznan, PolandDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Poznan, PolandIst Department of Cardiology, Poznan University of Medical Sciences, 61-848 Poznan, PolandDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Poznan, PolandBackground: Off-pump coronary artery bypass grafting (OPCAB) is believed to limit inflammatory reaction. Neutrophil to lymphocyte ratio (NLR) is one of the more common and easily accessible markers of inflammatory response. The aim of the study was to compare postoperative results of NLR with mid-term OPCAB results. Methods: In total, 224 patients (198 (88%) men and 26 (12%) women) with mean age 65 +/− 9 years who underwent OPCAB though median full sternotomy in our department in 2018 enrolled into the study. We scrupulously collected the postoperative mid-term results, including survival rate, clinical status and risk for major adverse events, and compared them with perioperative laboratory results. Results: A three-year follow-up was completed by 198 individuals (90% survival rate) with 12 (5%) showing major adverse cardiovascular (MACE) events risk. In the multivariable analysis, the laboratory parameters noticed on the 1st postoperative day were statistically significantly predictive of survival, including neutrophils (HR 1.59, 1.33–1.89 95%CI, <i>p</i> < 0.0001), platelets (HR 1.01, 1.01–1.01 95%CI, <i>p</i> = 0.0065), NLR (HR 1.47, 1.3–1.65 95%CI, <i>p</i> < 0.0001) and postoperative ejection fraction (HR 0.9, 0.87–0.95 95%CI, <i>p</i> < 0.0001). Conclusions: Postoperative NLR above 4.6, as an inflammatory reaction marker, is related to mid-term mortality in OPCAB patients.https://www.mdpi.com/2039-7283/11/3/74NLR 1OPCAB 2platelets 3LVEF 4 |
| spellingShingle | Tomasz Urbanowicz Michał Michalak Aleksandra Gąsecka Bartłomiej Perek Michał Rodzki Michał Bociański Ewa Straburzyńska-Migaj Marek Jemielity Postoperative Neutrophil to Lymphocyte Ratio as an Overall Mortality Midterm Prognostic Factor following OPCAB Procedures Clinics and Practice NLR 1 OPCAB 2 platelets 3 LVEF 4 |
| title | Postoperative Neutrophil to Lymphocyte Ratio as an Overall Mortality Midterm Prognostic Factor following OPCAB Procedures |
| title_full | Postoperative Neutrophil to Lymphocyte Ratio as an Overall Mortality Midterm Prognostic Factor following OPCAB Procedures |
| title_fullStr | Postoperative Neutrophil to Lymphocyte Ratio as an Overall Mortality Midterm Prognostic Factor following OPCAB Procedures |
| title_full_unstemmed | Postoperative Neutrophil to Lymphocyte Ratio as an Overall Mortality Midterm Prognostic Factor following OPCAB Procedures |
| title_short | Postoperative Neutrophil to Lymphocyte Ratio as an Overall Mortality Midterm Prognostic Factor following OPCAB Procedures |
| title_sort | postoperative neutrophil to lymphocyte ratio as an overall mortality midterm prognostic factor following opcab procedures |
| topic | NLR 1 OPCAB 2 platelets 3 LVEF 4 |
| url | https://www.mdpi.com/2039-7283/11/3/74 |
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