TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response

TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response

Translation initiation is the rate-limiting step of protein synthesis that is downregulated during the Integrated Stress Response (ISR). Previously, we demonstrated that most human mRNAs that are resistant to this inhibition possess translated upstream open reading frames (uORFs), and that in some c...

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Bibliographic Details
Main Authors: Dmitry E Andreev, Maxim Arnold, Stephen J Kiniry, Gary Loughran, Audrey M Michel, Dmitrii Rachinskii, Pavel V Baranov
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
uORF
TASEP
mRNA
integrated stress response
translation
eIF2
Online Access:https://elifesciences.org/articles/32563

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