Dissolution Test for Mianserin Hydrochloride in Tablets
A dissolution test for mianserin hydrochloride in coated tablets containing 30 mg was developed and validated using a fast ultraviolet spectrophotometric method. The appropriate conditions were determinate after testing sink conditions, agitation spped and dissolution medium. The sink conditions te...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universidade Federal do Rio Grande do Sul
2019-12-01
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| Series: | Drug Analytical Research |
| Online Access: | https://seer.ufrgs.br/index.php/produto&producao/ojs/include/index.php/dar/article/view/97029 |
| _version_ | 1797388930194079744 |
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| author | Letícia Lenz Sfair Caren Gobetti Martin Steppe Elfrides Schapoval |
| author_facet | Letícia Lenz Sfair Caren Gobetti Martin Steppe Elfrides Schapoval |
| author_sort | Letícia Lenz Sfair |
| collection | DOAJ |
| description |
A dissolution test for mianserin hydrochloride in coated tablets containing 30 mg was developed and validated using a fast ultraviolet spectrophotometric method. The appropriate conditions were determinate after testing sink conditions, agitation spped and dissolution medium. The sink conditions tested showed that mianserin hydrochloride was soluble in 0.01 and 0.1 M hydrochloric acid (HCl), acetate buffer pH 4.1 and 5.0 and phosphate buffer pH 6.8. Then, dissolution tests were performed to investigate the drug release in each medium. Optimal conditions to carry out the dissolution test were 900 mL 0.1 M HCl and USP apparatus 2 (paddle) at 50 rpm stirring speed. The quantification method was also adapted and validated. The UV method showed specificity, linearity, precision and accuracy. The in vitro dissolution test can be used to evaluate the drug release profile and the data was used as an aid to establish a possible correlation with in vivo data.
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| first_indexed | 2024-03-08T22:48:01Z |
| format | Article |
| id | doaj.art-37d88f22765a4f9a8ad5b2d244c1c92f |
| institution | Directory Open Access Journal |
| issn | 2527-2616 |
| language | English |
| last_indexed | 2024-03-08T22:48:01Z |
| publishDate | 2019-12-01 |
| publisher | Universidade Federal do Rio Grande do Sul |
| record_format | Article |
| series | Drug Analytical Research |
| spelling | doaj.art-37d88f22765a4f9a8ad5b2d244c1c92f2023-12-16T18:13:43ZengUniversidade Federal do Rio Grande do SulDrug Analytical Research2527-26162019-12-0132Dissolution Test for Mianserin Hydrochloride in TabletsLetícia Lenz Sfair0Caren Gobetti1Martin SteppeElfrides SchapovalUNISINOSUFRGS A dissolution test for mianserin hydrochloride in coated tablets containing 30 mg was developed and validated using a fast ultraviolet spectrophotometric method. The appropriate conditions were determinate after testing sink conditions, agitation spped and dissolution medium. The sink conditions tested showed that mianserin hydrochloride was soluble in 0.01 and 0.1 M hydrochloric acid (HCl), acetate buffer pH 4.1 and 5.0 and phosphate buffer pH 6.8. Then, dissolution tests were performed to investigate the drug release in each medium. Optimal conditions to carry out the dissolution test were 900 mL 0.1 M HCl and USP apparatus 2 (paddle) at 50 rpm stirring speed. The quantification method was also adapted and validated. The UV method showed specificity, linearity, precision and accuracy. The in vitro dissolution test can be used to evaluate the drug release profile and the data was used as an aid to establish a possible correlation with in vivo data. https://seer.ufrgs.br/index.php/produto&producao/ojs/include/index.php/dar/article/view/97029 |
| spellingShingle | Letícia Lenz Sfair Caren Gobetti Martin Steppe Elfrides Schapoval Dissolution Test for Mianserin Hydrochloride in Tablets Drug Analytical Research |
| title | Dissolution Test for Mianserin Hydrochloride in Tablets |
| title_full | Dissolution Test for Mianserin Hydrochloride in Tablets |
| title_fullStr | Dissolution Test for Mianserin Hydrochloride in Tablets |
| title_full_unstemmed | Dissolution Test for Mianserin Hydrochloride in Tablets |
| title_short | Dissolution Test for Mianserin Hydrochloride in Tablets |
| title_sort | dissolution test for mianserin hydrochloride in tablets |
| url | https://seer.ufrgs.br/index.php/produto&producao/ojs/include/index.php/dar/article/view/97029 |
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